摘要
目的探讨血清N末端B型钠尿肽(NT-proBNP)浓度与心功能分级(NYHA)、左室射血分数(LVEF)等临床指标之间的关系,及其在心力衰竭诊断中的作用。方法选择心衰患者200例、非心衰患者25例,采用电化学发光法测定血清NT-proBNP浓度。超声心动图测定受试者LVEF。依据NYHA分级方法对心衰患者进行心功能分级,心衰诊断依据病史、症状、体征、客观检查等做出的综合判断为金标准。结果心衰组的NT-proBNP水平显著高于对照组;NYHA分级与NT-proBNP水平呈显著正相关(r=0.992 0),LVEF则与NT-proBNP水平呈负相关。结论NT-proBNP可以客观准确地评价心功能,可作为临床诊断心衰的实验室指标。
Objective To investigate the relationship between the concentration of NT-proBNP, NYHA classification, left ventricular ejection fraction （LVEF） and the value of NT-proBNP in the evaluation of cardiac function and the diagnosis of heart failure. Methods Two hundred heart failure patients and twenty-five non heart failure patients were selected. The concentration of NT-proBNP was determined by an automated eleetrochenil immunoassayan Roche Elecsys 2010. LVEF was measured by the modified Simpson＇ s equation with .eehocardiography. The diag nosis of clinical physician was considered to be the golden standard for heart failure. Results The concentration of heart failure was significantly higher than controls; NT-proBNP showed positive correlation with NYHA classification（ r = 0,992 0）, and negative correlation with LVEF. Conclusion NT-proBNP is a valuable biomarker for the evaluation of cardiac function and the diagnosis of heart failure.
出处
《实用药物与临床》
CAS
2007年第1期11-12,共2页
Practical Pharmacy and Clinical Remedies
关键词
钠尿肽
心力衰竭
心功能分级
NT-proBNP
Heart failure
Cardiac function classification
