期刊文献+

心力衰竭患者尿NT-proBNP的测定及临床意义 被引量:5

下载PDF
导出
摘要 目的探讨尿N末端B型钠尿肽原(NT-proBNP)在心力衰竭诊断中的应用价值。方法采用电化学发光法检测80例慢性心力衰竭患者(心衰组)及40例查体健康者(对照组)血清和尿NT-proBNP水平。结果心衰组尿NT-proBNP水平明显高于对照组(P<0.01),与血清NT-proBNP水平呈正相关(r=0.76,P<0.01),与心功能NYHA分级呈正相关(r=0.71,P<0.01)。尿NT-proBNP受试者工作特征(ROC)曲线分析示曲线下面积AUC=0.92±0.02,心力衰竭的诊断界值为70.5pg/ml,灵敏度为85%,特异度为90%。结论尿NT-proBNP可作为心力衰竭的一个新标记物;在心力衰竭诊断和心功能状态评估中有重要应用价值。
出处 《山东医药》 CAS 北大核心 2009年第39期62-63,共2页 Shandong Medical Journal
  • 相关文献

参考文献2

二级参考文献15

  • 1Sudoh T, Kangawa K, Minamino N, et al. A new natriuretic peptide in porcine brain. Nature, 1988, 332:78-81. 被引量:1
  • 2Mukoyama M, Nakao K, Saito Y, et al. Increased huan brain natriuretic peptide in congestive heart failure. N Engl J Med, 1990,323:757-758. 被引量:1
  • 3Morrison KL,Harrison A,Krishnaswany P,et al. Vtility of a rapid B-natriuretic peptide (BNP) assay in differentiating CHF from lung disease in patients presenting with dyspnea. J Am Coll Cardiol,2002, 39:202-209. 被引量:1
  • 4Maisel AS, Koon J, Krishnaswamy P, et al. Utility of B-natriuretic poptide as a rapid, point-of-care test for screening patients undergoing echocardiography to determine left ventricular dysfunction. Am Heart J, 2001, 141:367-374. 被引量:1
  • 5Joung BY, Park BE, Kim DS, et al. B-type Natriuretic peptide predicts clinical presentations and ventricular overloading in patients with Heart Failure. Yonsei Medical J, 2003, 44:623-634. 被引量:1
  • 6Groenning BA, Nilsson JC, Sondergaavd L, et al. Evaluation of impaired left ventficular ejection fraction and increased dimensions by multiple neurohumoral plasma concentrations. European Journal of Heart Failure, 2001,3:699-708. 被引量:1
  • 7McDonagh TA, Robb SD, Murdoch DR, et al. Biochemical detection of left-ventricular systolic dysfunction. Lancet, 1998,351 :9-13. 被引量:1
  • 8Ry SD, Clerico A, Giannessi D, et al. Measurement of brain natriuretic peptide in plasma samples and cardiac tissue extracts by means of an immunoradiometric assay method. Scand J Clin Lab Invest, 2000, 60 : 81-90. 被引量:1
  • 9Fonseca C, Sarmento PM, Minez A ,et al. Comparative value of BNP and NT-proBNP in diagnosis of heart failure. Rev Port Cardiol,2004, 23:979-91. 被引量:1
  • 10de Bold A J, Bnmeau BG, de Bold MLK. Mechanical and neurocndocrine regulation of the endocrine heart. Cariovasc Res,1996, 31:7-18. 被引量:1

共引文献165

同被引文献60

引证文献5

二级引证文献32

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部