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老年局部晚期非小细胞肺癌适形放疗协同诱导化疗的临床观察 被引量:12

Clinical Observation of Conformal Radiotherapy with Co-induction Chemotherapy on Elderly Patients with Locally Advanced Non-small Cell Lung Cancer
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摘要 目的:评价三维适形放疗协同诱导化疗治疗老年局部晚期非小细胞肺癌的近期疗效。方法:回顾性分析不能手术或拒绝手术的老年非小细胞肺癌128例,分为两组,Ⅰ组单纯三维适形放疗70例,Ⅱ组诱导化疗协同三维适形放疗58例。观察两组的近期疗效、不良反应及1、2年生存率。结果:Ⅰ组CR41.4%,PR32.8%,总有效率(CR+PR)74.3%;Ⅱ组CR51.7%,PR31.0%,总有效率(CR+PR)82.8%,两组间差异无统计学意义(P=0.248)。1年生存率Ⅰ组为41.4%,Ⅱ组为56.9%,两组间差异无统计学意义(P=0.081);2年生存率Ⅰ组为27.1%,Ⅱ组为44.8%,两组间差异有统计学意义(P=0.037)。结论:三维适形放疗协同诱导化疗是老年局部晚期非小细胞肺癌可选择的治疗方法,与单纯放疗相比可延长生存期,但远期疗效仍需要进一步观察。 Objective: To evaluate the effect of co-induction chemotherapy followed by 3-dimensional conformal radiation therapy (3DCRT) for elderly patients with locally advanced non-small-cell lung cancer. Methods: A retrospective analysis of 128 patients treated with 3DCRT in combination with the co-induction chemotherapy was conducted. All the 128 patients were 60 years or older. They were treated with radiation therapy alone (group Ⅰ, 70 cases) or chemoradiotherapy (group Ⅱ, 58 cases), respectively, Results: The overall response rate was 74.3% in group Ⅰ and was 82.8%in group Ⅱ(P= 0.248). The 1-year overall survival rate was 41.4% in group Ⅰ and was 56.9% in group Ⅱ, respectively (P=0.081). There was no statistical difference in the overall response and the 1-year overall survival rate between the two groups. The 2-year overall survival rate was 27.2% in group Ⅰ and was 44.8% in group Ⅱ, respectively (P=0.037). There was a statistical difference between the two groups. Conclusion: The 3-DCRT with co-induction chemotherapy will be an optimal therapy and may extend the life span compared to simple radiotherapy, but further observation of the prostecdtive efficacy is needed.
出处 《中国肿瘤临床》 CAS CSCD 北大核心 2006年第22期1294-1296,共3页 Chinese Journal of Clinical Oncology
关键词 非小细胞肺癌 老年 立体适形放射治疗 诱导化疗 Non-small-cell lung cancer/elderly patients Three-dimensional conformal radiation therapy(3DCRT) Co-induction chemotherapy
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