摘要
27例急性心肌梗塞患者用链激酶溶栓治疗,其中20例联合静脉滴注乙酰半胱氨酸(NAC)。结果显示:联合应用NAC治疗后血浆还原型谷胱甘肽(GSH)及GSH与氧化型谷胱甘肽(GSSG)之比(GSH/GSSG)显著性增高(P<0.05),伴随GSSG显著性降低(P<0.05)。NAC治疗组心指数亦明显高于对照组(P<0.01)。
Twentysevenpatientswithacutemyocardialinfarction(AMI),admitedtocoronarycareunit,weretreatedwith(n=20)orwithout(n=7)intravenouslyinfusedN-acetylcysteine(NAC),asanadjuncttonitroglycerine(NTG)andstreptokinase.InpatientsreceivingNAC,plas-mareducedglutathione(GSH)andtheratioofGSHtooxidizedglutathione(GSH/GSSG)increasedsignificantly(P<0.05)asociatedwithsignificantreductionofGSSG(P<0.05).TheseresultsshowedthatNACincombinationwithNTGandstreptokinaseintreatingpatientswithAMIisaso-ciatedwithlessoxidativestress.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
1996年第4期282-284,共3页
Chinese Journal of Cardiology
关键词
心肌梗塞
乙酰半胱氨酸
溶栓术
myocardialinfarctionN-acetylcysteinethrombolytictherapy