摘要
目的:检测急性冠脉综合征(ACS)患者血清中血管细胞黏附分子(VCAM-1)、细胞间黏附分子(ICAM-1)及C反应蛋白(CRP)水平,探讨其变化在冠心病(CHD)发病及诊断中的意义。方法:检测50例经冠脉造影证实为ACS患者血清中VCAM-1、ICAM-1和CRP的水平,以50例经冠脉造影正常者作对照。结果:ACS患者血清中VACM-1、ICAM-1和CRP水平明显高于对照组,分别为(701±54.6)和(556±42.2)μg.L-1(P<0.01)、(389±23.7)和(271±34.6)μg.L-1(P<0.01)及(7.05±3.13)和(4.22±1.41)mg.L-1(P<0.01);急性心肌梗塞(AMI)与不稳定心绞痛(UA)患者VCAM-1和ICAM-1无统计学差异[(699.12±62.77)和(706.57±53.65)、(390.39±42.34)和(372.63±32.59)μg.L-1](P>0.05);AMI患者CRP含量明显高于UA患者[(8.06±2.78)和(6.33±2.01)mg.L-1](P<0.05)。结论:动脉粥样斑块所致的动脉狭窄和闭塞病变伴随着介导血管炎症的VCAM-1、ICAM-1及CRP水平的增高,并且与病变严重程度相关,其过度表达可能是动脉粥样硬化(AS)发生的重要因素之一,有望成为动脉粥样硬化发生发展和病情监测指标。
Objective To measure the levels of serum vascular cell adhesion molecule-1 （VACM-1）, intercellular adhesion molecule-1 （ICAM-1） and C-reactive protein （CRP） in patients with acute coronary syndrome （ACS）, and to explore their significances in diagnosis and treatment of coronary heart disease. Methods The levels of serum VACM-1, ICAM-1 and CRP were measured in 50 patients with ACS undergoing coronary angiography as well as 50 controls. Results The levels of serum VACM-1, ICAM-1 and CRP in patients with ACS were higher than those incontrols （701±54.6 /μg·L^-1 vs 556±42.2 /μg·L^-1, 389±23.7 /μg·L^-1 vs 271±34.6μg·L^-1, 7.05± 3.13 mg·L^-1 vs 4.22± 1.41 mg·L^-1） （P〈0.01）; the levels of VACM-1 and ICAM-1 between acute myocardial infraction （AMI） and unstable angina （UA） patients were not difference （699.12＋62.77 μg·L^-1 vs 706.57±53.65μg·L^-1, 390. 39±42. 34μg·L^-1 vs 372. 63±32. 59μg·L^-1） （P〉0.05）; CRP content in AMI patients was higher than that in UA patients （8.06±2.78 mg· L^-1 vs 6.33±2.01 mg · L^-1） （P〈0.05）. Conclusion The stenosis and block caused by atherosclerosis plaque accompany the increase of VACM-1, ICAM-1 and CRP, and there is a relation with condition of the disease. The excess expression of adhesion molecules may be an important factor of atherosclerosis. Adhesion molecule might become a test index to monitor the occurrence and development of atheroselerosis.
出处
《吉林大学学报（医学版）》
CAS
CSCD
北大核心
2005年第5期799-801,共3页
Journal of Jilin University：Medicine Edition
基金
吉林省卫生厅资助课题(2002045)
