摘要
目的:探讨子宫内膜异位症的发病机理。方法:对28例子宫内膜异位症的在位内膜和异位内膜进行病理组织学发育日期评定,对其中15例采用免疫组化ABC法测定雌激素受体(ER)、孕激素受体(PR)水平,并进行比较。结果:异位内膜较在位内膜发育落后的有19例(67.9%),提前的4例(14.3%),仅5例(17.9%)相符合;ER、PR水平异位内膜较在位内膜低,在腺体细胞中的差别有显著性(P<0.01,P<0.05),在间质细胞中无明显差别(P>0.05)。结论:免疫组化ABC法可对受体定位,在异位内膜ER、PR研究上优于葡聚糖活性碳吸附(DCC)法,异位内膜不同于在位内膜可能与发病机理及局部激素环境有关。
Objective:Tostudythediferencesofhistologicdatingandsteroidreceptorsbe-tweenectopicandeutopicendometriuminpatientswithendometriosis.Methods:Histologicexamina-tionsweredoneoneutopicandectopicendometriumin28patientswithpelvicendometriosis,andes-trogenandprogestronereceptorsconcentrationsweredeterminedbyimmunochemicalABCmethodin15patients.Altheectopictissueswerebiopsiedfromperitoneallesions.Results:In67.9%pa-tients,theectopicendometriumdevelopmentwasretardatedand14.3%acceleratedascomparaedwitheutopicendometrium,andonly17.9%identical.Theestrogenreceptors(ER)andprogesteronereceptors(PR)contentsofectopicendometriumweresignificantlylowerthanthoseofeutopicen-dometriuminglandularcels(P<0.01,P<0.05respectively),whiledifferenceswerenotsignificantinstromacels.Conclusions:Theadvantageoftheimmunochemicaltechniqueisthatitcandefinitelylocatethesiteofreceptorsinthehistologicsection.ThediferenceinhistologicdatingandERandPRconcentrationsintheeutopicandectopicendometriummaybeaccountedforbythediferentsteroidenvironmentsandpathogenictheoryofperitoneummetaplasia.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1996年第10期582-585,共4页
Chinese Journal of Obstetrics and Gynecology