摘要
目的:探讨泛素(Ub)、孕激素受体(PR)在子宫内膜异位症发病机制中的作用。方法:采用免疫组化方法检测35例内膜异位症患者的在位及异位内膜、26例正常子宫内膜中Ub与PR的表达情况。结果:正常子宫内膜的Ub表达呈现周期性变化;内膜异位症组在位与异位内膜的Ub表达均高于正常组,PR表达显著低于正常组(P<0.05),尤以间质细胞的差异为明显(P<0.05)。结论:内膜异位症异位内膜中Ub的高表达与PR的低表达促进了内膜异位症的发生;Ub对PR可能存在降调节;间质细胞在内膜异位症的形成过程中可能发挥了重要作用。
Objective： To investigate the effect of ubiquitin （Ub） and progesterone receptor （PR） in the pathogenesis of endometriosis and the relationship between these two signals. Methods： The expression of Ub and PR in normal endometrium（26 cases）, eutopic and ectopic endometrium of endometriosis（35 cases） were detected by immunohistological analysis. Results： Ub expressed cyclic changes in normal cases. The expression of Ub was higher and PR was lower in both eutopic and ectopic endometrim of endometriosis than that of controls （P〈0.05）, especially in stromal cells. Conclusion： This study indicates that the increased expression of Ub and decreased expression of PR in eutopic and ectopic endometrium might play an important role in pathogenesis of endometriosis. Stromal cells may be contributed to the development of endometriosis.
出处
《天津医科大学学报》
2006年第3期413-416,共4页
Journal of Tianjin Medical University
关键词
泛素
孕激素受体
子宫内膜异位症
免疫组化
Ubiquitin
Progesterone receptor
Endometriosis
Immunohistochemistry
