摘要
以内型异莰烷基甲醇为原料,先与HBr反应转变成内型异莰烷基一溴甲烷,再与NaCN在乙醇中反应转变成内型异莰烷基乙腈(3),两步反应的得率均接近90%。使(3)与格氏试剂反应,水解后得内型α-异莰烷基酮,再用NaBH_4将其还原又合成了内型β-异莰烷基醇。这是两类文献未见报道的新型异莰烷类化合物,各产品都进行了纯化和结构分析。
Starting from endo-isocamphanyl methanol, endo-isocamphanyl acetonitrile (3) was prepared by bromination of endo-isocamphanyl methanol with hydrobromic acid and cyanidation with sodium cyanide in excellent yield. Then, endo-a-isocamphanyl ketones (4) were synthesized through Grignard reaction of (3) with Grignard reagents and subsequent hydrolysis. Moreover, endo-β-isocamphanyl alcohol (5) was obtained by reduction of (4) with sodium borohydride. All new compounds (4) and (5) were purified and identified.
出处
《林产化学与工业》
EI
CAS
CSCD
北大核心
1996年第3期19-23,共5页
Chemistry and Industry of Forest Products
基金
江西省自然科学基金
关键词
香料
异莰烷基醇
合成香料
异莰烷基酮
Substitution
Grignard reaction
Reduction
Synthetic perfume