摘要
为了观察无（弱）应答者对乙肝疫苗再接种的反应，于１９８９年对原接种过三针血源性乙肝疫苗的１０名无（弱）应答者和１８名原应答良好者共计２８人再接种一针血源性乙肝疫苗．于复种后２、６、１２、３６个月进行了随访观察，三年结果显示：无（弱）应答者和原应答良好者复种后抗－ＨＢｓ水平均有所升高，但无（弱）应答者抗体滴度较低，且持续时间较短；而应答良好者复种后第３６个月时抗体仍处于保护水平以上。因此认为用复种方法提高无（弱）应答者的抗体水平难以达到理想结果。
In order to study the response of revaccination of nonresponders and hyporesponders tohepatitis B vaccine,a total of 28 persons including 10 nonresponders and hyporesponders and18 previously normal responders were revaccinated one dose plasma-derived hepatitis B vac-cine in 1989.All of them were given three injections of hepatitis B vaccine three years ago. Allthe subjects were followed up and examined in 2,6,12 and 36 months after revaccination.The results showed:anti-HBs levels were increased both in nonresponders and hyporespon-ders group as well as previously normal responder group after revaccination. But the antibodytiters of nonresponders and hyporesponders were lower and the duration of persistence wasshorter as compared with previously normal responders. The antibody titers of previouslynormal responders in 36 months after vaccination were still above protective levels. There-fore,it is hard to conclude that revaccination could significantly boost the antibody levels ofnonrespongdrs and hyporesponders.
出处
《解放军预防医学杂志》
CAS
北大核心
1996年第4期253-257,共5页
Journal of Preventive Medicine of Chinese People's Liberation Army
关键词
乙肝疫苗
乙型肝炎
接种
hepatitis B vaccine,nonresponders and hyporesponders,revaccination
