摘要
目的 :了解本地区乙肝疫苗免疫效果。方法 :取自天津市传染病院咨询门诊 ,2 69例均为HBs Ag、HBs Ab阴性、肝功能正常之接种者 ,按“0 ,1 ,6”免疫程序于上臂三角肌肌内注射接种 ,除首剂量分为 1 0 μg与 5μg组外 ,后两次注射量均为 5μg。结果 :(1 )～ 1 0岁组 HBs Ab最高 ,～ 40岁组最低 ,两者均值相差 6倍以上 ,但从总体趋势分析 ,随年龄升高 ,抗体应答能力逐渐下降。 (2 )有 HBV感染史者接种乙肝疫苗 ,其 HBs Ab应答能力较乙肝系列检查全阴者为强。 (3)首剂量 1 0 μg组无论是 3个月 ,还是 7个月 ,HBs Ab水平和阳性率均高于 5μg组。 (4)性别不是影响接种效果的因素。结论 :乙肝疫苗的接种 ,以 2 0岁以前为佳 ,而且尽量接种不少于 3次 ,首剂量不应少于 1
Objective:To investigate the effect of injecting Hepatitis B vaccination in Tianjin area.Methods:Cases were selected from the clinics of Infectious Disease HospitalAll 269 participants were HbsAg negative, HbsAb negative, and have normal liver function testsThey were vaccinated at 0, 1, and 6 months intervals on the deltoidThe initial vaccination dosage were 5μg and 10μg respectively in the two groupsThe second and third dosages at 1 and 6 months were 5μg in both groupsResults:(1) The level of HbsAb was the highest in the 10 yearsold group, lowest in the 40 yearsold groupThe average antibody titer of the two groups differed by six foldOverall, as age increased, the ability to produce antibody decreased(2) Cases with history of HBV infection had higher HbsAb titer after vaccination compared to the another without history of HBV infection(3) In cases who received 10μg as the initial vaccination dose, the percentage of people with positive antibody titer and the level of titer were higher than the group who received 5μg as the initial dose (4) There were no difference in vaccination results in the two different gender groupsConclusion: Results of Hepatitis B Vaccination is the best when one is vaccinated before age 20, the series of vaccination not less than 3, and the initial dosage not less than 10μg
出处
《天津医科大学学报》
2000年第1期57-59,共3页
Journal of Tianjin Medical University
关键词
乙肝疫苗
相关因素
首剂量
乙型肝炎
hepatitis B vaccination
correlative factor
initial olosagee
