摘要
[目的]探讨茶多酚的促排镉作用及对肝肾损伤的影响.[方法]取60只清洁级SD系大鼠,按体重大小随机分为：①正常对照组;②茶多酚组;③单染镉组;④～⑥低、中、高剂量茶多酚干预组.5周干预结束后,收集24 h尿液、粪便,取肝、肾、睾丸测定相关指标.[结果]中高剂量干预组肝镉和睾丸镉含量低于单染镉组（P＜0.05）,尿镉和粪镉高于单染镉组（P＜0.05）,且具量效关系.肾镉含量干预组与单染镉组类似;茶多酚组肝镉含量低于正常对照组（P＜0.05）.肝肾检查ALT、AST、BUN、CRE干预组与单染镉组类似.[结论]中高剂量茶多酚可促进染镉与正常大鼠的镉排出,同时不加重肝肾损伤.
[Objective] To study the effects of promoting cadmium excretion by tea polyphenols （TP） and the influence on liver and kidney. [Methods] Sixty SD rats were randomly divided into 6 groups： ① Group-control; ② Group-TP; ③ Group-Cd; ④ to ⑥ Group-intervention （low, medium and high dose）. After 5 weeks, the serum, 24 h urine, feces, liver, kidney and testis were taken for examining. [Results] The Cd level of liver and testis for Group-medium and high-dose TP were lower than that of Group-Cd （P 〈 0.05）, and Cd levels in urine and feces were higher than that of Cd group （P 〈 0.05）, and showed dose-response relationship. The Cd levels in kidney and bone for Group- intervention were similar to Group-Cd. The Cd level in liver for Group-TP was lower than Group-controh The serum level of ALT、AST、BUN、CRE for Group intervention were similar to Group-Cd. [Conclusion] Group-TP for medium and high dose can promote Cd excretion without increasing damage of liver and kidney.
出处
《海峡预防医学杂志》
CAS
2006年第5期3-5,共3页
Strait Journal of Preventive Medicine
关键词
镉中毒
茶多酚
疾病控制
Cadmium Poisoning
Tea Polyphenols （TP）
Disease Control
