摘要
目的：探讨2型糖尿病患者大血管病变与血浆C反应蛋白（CRP）的关系及辛伐他汀保护血管作用的机制。方法：选择2型糖尿病（T2DM）患者69例，其中单纯T2DM组（A组）34例，T2DM并发大血管病变组（B组）35例，并选择20名健康体检者为对照组（C组）。采用免疫比浊法测定三组血清CRP水平，并观察辛伐他汀治疗A、B组前后CRP、血脂的变化。结果：A组和B组血清CRP水平均高于C组（P〈0．05和P〈0．01），B组也明显高于A组（P〈0．01）。血清CRP与胆固醇（TC）、低密度脂蛋白（C-LDL）、氧化低密度脂蛋白（OX—LDL）、收缩压（SBP）、体重指数（BMI）均呈正相关关系（P〈0．05～P〈0．01），与高密度脂蛋白（C—HDL）呈负相关关系（P〈0．01）。辛伐他汀治疗后血清CRP、TC、LDL和ox-LDL均明显下降（P〈0．01）。结论：血清CRP水平的检测对监测T2DM大血管病变的发生、发展有重要的临床意义。辛伐他汀通过抗炎、抗氧化及调脂作用而发挥其对T2DM大血管的保护作用。
Objective： To investigated the relationship between serum C-reactlve protein （CRP）and macroangiopathy of type 2 diabetes millitus,and the mechanism of Simvastatin in protection of blood vessels. Methods：Sixty-nine cases of type 2 diabetes mellitus were selected, 34 of whom had only type 2 diabetes with no complications （group A ） and 35 of whom were accompanied by macroangiopathy（ group B）, and 20 healthy subjects acted as controls （group C）. The serum CRP was determined by immunoturbidimetric. The changes were observed before and after simvastatin treatment. Results：The serum CRP in group A and B were higher than that in group C（ P 〈 0.05 and P 〈 0.01 ） ,while group B had higher serum CRP levels than group A（ P 〈 0.01 ）. Serum CRP had a positive correlation with TC, C-LDL, ox-LDL, SBP, BM1 （ P 〈 0. 05 to P 〈 0. 01 ） , and had a negative correlation with C-HDL（ P 〈 0. 01 ）, After simvastatin treatment, the levels of serum CRP, TC, C-LDL, ox-LDL reduced remarkably （ P 〈 0.01 ）. Conclusions： Senlm CRP may play an important role in the development and progression of type 2 diabetic macroangiopathy. Simvastation protects the blood vessel by its mechanism of anti-inflammation, anti-oxidation and moderating lipid,
出处
《蚌埠医学院学报》
CAS
2006年第6期618-620,共3页
Journal of Bengbu Medical College
