摘要
目的:探讨慢性阻塞性肺疾病(COPD)急性发作期患者血清中的白细胞介素2(IL-2)和白细胞介素8(IL-8)、C反应蛋白(CRP)水平变化及与肺功能的相关性。方法:检测COPD组治疗前、后(n=34)和对照组(n=32)血清IL-2和IL-8、CRP水平,以及与第1秒用力呼吸量占预计值的百分比的相关分析。结果:①COPD组治疗前血清IL-2和IL-8、CRP水平均高于对照组,有明显统计学差异(P<0.05)。COPD组IL-2和IL-8、CRP水平与FEV1/pre%呈负相关(r=-0.814,P<0.05);②COPD组IL-2和IL-8、CRP水平治疗前、后有显著统计学差异(P<0.05);③COPD组治疗后血清IL-2和IL-8、CRP水平均高于对照组,有明显统计学差异(P<0.05)。结论:COPD气道炎症与IL-2和IL-8、CRP水平释放增多有关,检测血清IL-2、IL-8、CRP水平可作为判断COPD预后的指标。
Objective：To investigate the relationship between serum levels of interleukin-2（IL-2）,interleukin-8（IL-8）,CRP and pulmonary function in patients with acute exacerbation of chronic obstructive pulmonary disease（COPD）.Methods：Serum levels of IL-2,IL-8 and CRP were detected from 34 cases of acute exacerbation of COPD （COPD group） and 32 cases of normal volunteers （control group） before and after treatment.FEV1/pre% was correlated anlyzed.Results：① Serum levels of IL-2,IL-8 and CRP in patients with acute exacerbation of COPD before treatment were significantly higher than those in control group （P0.05）.Serum level of IL-2,IL-8 and CRP revealed notably negative correlated with FEV1/pre% （r=-0.814,P0.05）.② There was significant difference in levels of IL-2,IL-8 and CRP before and after treatment in COPD group （P0.05）.③ Serum level of IL-2,IL-8 and CRP were higher after treatment in COPD group than those in control group （P0.05）.Conclusions：The increased levels of IL-2,IL-8 and CRP play certain role in acute exacerbation of COPD.They may be indicators in judging the prognosis of COPD.
出处
《内科急危重症杂志》
2010年第1期34-35,50,共3页
Journal of Critical Care In Internal Medicine
关键词
慢性阻塞性肺疾病
白细胞介素2
白细胞介素8
C反应蛋白
肺功能
Chronic obstructive pulmonary disease Interleukin-2 Interleukin-8 C-reactive protein Pulmonary function
