摘要
目的通过动物实验探讨纳米陶瓷人工骨的骨缺损修复作用及相关问题,为其应用于骨缺损的修复提供依据。方法青紫兰兔45只在单侧桡骨制备骨缺损动物模型,随机分成3组(每组15只),然后用纳米陶瓷人工骨材料植入骨缺损处进行修复作为实验组,以植入陶瓷人工骨为对照组,空白组不植入任何材料;术后4、8、12周分别行大体标本观察、组织学、X线检查、扫描电镜(SEM)测试,比较三组间骨缺损区的成骨情况。结果纳米陶瓷人工骨成骨作用明显优于陶瓷人工骨组和空白对照组,差异有显著性意义(P<0．05)。结论纳米陶瓷人工骨具有良好的成骨能力、生物相容性和一定的降解率,是一种替代自体骨修复骨缺损较理想的材料。
Objective To study the feasibility of applying nanometer ceramics artificial bone in clinical repair of bone defects. Methods The animal models of bone defect was made on the unilateral radius of 45 New Zealand white rabbits, which were divided into experimental group（repair with nanometer ceramics artificial bone）, control group（repair with ceramics artificial bone）and blank group （unrepaired） randomly. The reconstructive effect in each group was evaluated by gross observation, alkaline phosphatase（ALP） detection of blood serum, histopathological observation, X-ray examination and SEM detection at 4th, 8th and 12th weeks postoperatively. Results In the experimental group there was more bone formation than in the control and the blank groups. The differences in reconstructive effect were statistically significant （ P 〈 0. 05 ） . Conclusion As the nanometer ceramics artificial bone has fine bone reconduction ability and biocompatibility as well as some degradability, it can be used as a good alternative to autografts in treatment of bone defects.
出处
《中华创伤骨科杂志》
CAS
CSCD
2006年第11期1048-1052,共5页
Chinese Journal of Orthopaedic Trauma
基金
深圳市科技计划项目(200304061)
广东省卫生厅科技项目(2003704)
关键词
纳米材料
陶瓷
人工骨
骨缺损
Nano-material
Ceramics
Artificial bone
Bone defect
