摘要
目的:探讨基质金属蛋白酶-7(MMP-7)表达与大肠癌进展及预后的关系。方法:采用免疫组织化学技术检测81例大肠癌标本中MMP-7的表达情况。结果:MMP-7表达与大肠癌的淋巴结转移、远处转移、Dukes分期呈正相关(P<0.05-0.01);粘液癌MMP-7的表达明显高于高分化腺癌(P<0.01);年龄低于60岁的大肠癌患者MMP-7的表达显著高于60及60岁以上者(P<0.05)。结论:MMP-7促进了大肠癌的生长和转移,可作为大肠癌的预后评估因子。
Objective：To explore the relationships between matrix metaUoproteinases-7 （MMP-7） ex- pression and development, prognosis of colorectal carcinoma （CC）. Methods： SP immunohistochemical technique was used to detect the MMP-7 expressions of 81 cases of CC paraffin-embedded specimens. Re- suits： The expression of MMP-7 in CC had positive correlation with lymph node metastasis, distant metastasis and Dukes＇stage （P〈0. 05-0. 01）. The expression of MMP-7 in mucinous carcinoma was obviously higher than in well-differentiated adenocarcinoma （P〈0.01）. The MMP-7 expression of patients aged below 60 was significantly higher than in patients aged 60 and over 60 （P〈0. 05）. Conclusions： MMP-7 can promote the growth and metastasis of CC and can be a prognostic factor of CC.
出处
《承德医学院学报》
2006年第4期341-343,共3页
Journal of Chengde Medical University
