摘要
目的：探讨基质金属蛋白酶在鼻咽癌表达的意义。方法：采用免疫组织化学法对２６ 例鼻咽癌组织进行标记及分析。结果：显示 Ｍ Ｍ Ｐ９ 和 Ｍ Ｍ Ｐ２ 与鼻咽癌的侵润及转移密切相关。 Ｍ Ｍ Ｐ９ 和 Ｍ Ｍ Ｐ２ 阳性表达率，淋巴结转移组明显高于无淋巴结转移组；低分化鳞癌高于高分化鳞癌。结论：表明 Ｍ Ｍ Ｐ９ 和 Ｍ Ｍ Ｐ２ 在鼻咽癌细胞突破基底膜向外扩散及转移中起着重要作用，两者参与了鼻咽癌的转移过程。
Objective:To evaluate the role of matrix metalloproteinase (MMP) in the invasion and metastasis of nasopharyngeal carcinoma (NPC).Method:Twenty six cases of NPC were studied by immunohistochmical method using monocolonal antibody to MMP2 and MMP9.Result:It was showed that there were significantly correlation between MMP2 or MMP9 and the invasion and metastasis of NPC.The positive rate of MMP2 and MMP9 were higher in NPC with cervical lymph node involvement than that of no cervical lymph node involvement.And they were lower in well differentiated NPC than poorly differentiated NPC.Conclusion:The results indicate that MMP2 and MMP9 may play a critical role in assisting carcinoma cell to degrade basement membrane to invade surrounding tissues and to form metastatic colonies in lymph nodes.
出处
《临床耳鼻咽喉科杂志》
CSCD
1999年第8期356-358,共3页
Journal of Clinical Otorhinolaryngology
