摘要
趋化因子CXCL9又称为Mig,即monokineinducedbyIFN-γ(IFN-γ诱导的单核因子),是趋化因子CXC亚族的一员,体内主要由IFN-γ刺激的巨噬细胞和神经胶质细胞产生,体外则可由内皮细胞、粒细胞等在IFN-γ和TLR配体协同作用下产生。CXCL9的受体CXCR3为七次跨膜的G蛋白偶联受体。CXCL9对激活的T淋巴细胞和肿瘤浸润淋巴细胞具有趋化作用,但是对粒细胞和单核细胞没有作用。主要就CXCL9的结构与生化特征,其在免疫、移植排斥、肿瘤治疗等方面所起的作用,进行了较为系统的综述。
Chemokine CXCL9/Mig （monokine induced by IFN-γ） belongs to the subfamily of chemotactic cytokines known as CXC-chemokines. In vivo CXCL9 is mainly induced by IFN-γ in macrophages and primary glial cells. In vitro, CXCL9 can be secreted by cells such as macrophages, microvascular endothelial cells and neutrophils, in response to the synergy of IFN-γ and TLR （toll-like receptor ） ligands. CXCL9 is a chemoattractant for activated T lymphocytes, tumor-infiltrating T-lymphocytes, but not for neutrophils or monocytes. The receptor specific for CXCL9 is CXCR3, a G protein-coupled protein which has seven transmembrane domain. The structure and the chemical characterization of CXCL9, as well as its effects on autoimmune deseases, allograft rejection, cancer therapy were reviewed.
出处
《中国生物工程杂志》
CAS
CSCD
北大核心
2006年第10期59-63,共5页
China Biotechnology
基金
国家自然科学基金资助项目(C03020705)
上海市科委基金资助项目(04DZ19203)
