摘要
胃镜下取221例良性胃病的活检组织进行HE染色、Geimsa染色查HP,CEA单克隆抗体免疫组化检查(ABC法).结果:HP感染率77.38%(17/221),CEA阳性率38.91%(86/221),肠化生(IM)和/或不典型增生(AH)发生率26.70%(59/221),HP阳性与阴性病变的IM和/或AH发生率分别为30.41%(52/171)及14.00%(7/50)(P<0.05).HP阳性与阴性病变的CEA阳性率分别为43.27%(74/171)和24.00%(12/50)(P<0.01).提示HP感染与胃的癌前病变的发生及CEA的表达相关.
The gastric biopsy specimens of 221 patients with benign gastric disorders were used for H-E staining, Geimsa staining to detect helicobacter pylori (HP), staining with monoclonal carcino-embryonic antigen (CEA) by the immunohistocliemical ABC method. Our results reveal that the prevalence of HP infection was 77. 38% (171/221); the positive rate of CEA was 38.91 % (86/221) ;the incidence of intestinal metaplasia(im) and/or atypical hyperplasia(AH) was 26.70% (59/221); the incidences of IM and/or AH in the lesions with and without HP infection were 30.41 % (52/171) and 14.00% (7/50) respectively(P<0.05). The CEA positive rates in the lesions with and without HP infection were 43.27% (74/171) and 24. 00 % (12/50) respectively (P < 0.01). Our results suggest that HP infection is related to the high expression of CEA and the occurrence of gastric precancerous lesions.
出处
《临床消化病杂志》
1996年第4期151-152,共2页
Chinese Journal of Clinical Gastroenterology
关键词
曲门螺杆菌
癌前病变
癌胚抗原
Helicobacter pylori Precancerous lesions Carcino-embryoni cantigen
