摘要
实验用１６０只Ｗｉｓｔａｒ大鼠自由饮用。０．１％氨水８周造成实验性慢性胃炎。实验兮预防和治疗两部分进行观察，预防组于诱发胃炎的同时用２０％胃康、维霉素水溶液２ｍｌ隔日灌胃。治疗组干饮用氨水８周后，每日分别用３０％胃康，维霉素水溶液２ｍｌ灌胃治疗４周。实验结束后分别取胃观察其病理组织学变化。结果显示：在胃康组的预防和治疗两部分与模型组比较，其粘膜厚度增高（Ｐ＜０．０５），壁细胞计数增多（Ｐ＜０．０５），细胞内ＡＢ／ＰＡＳ阳性物增加（Ｐ＜０．０５），粘膜上皮病变减轻（Ｐ＜０．０５）。结果说明胃康对大鼠实验性慢性胃炎有一定的防治作用，并为该药的临床应用提供了实验依据。
60Wistar rats were given 0. l%ammonia solution as drinking at libitum for eight weeks to make theexperimental model. This rearch included two parts. The first one studied the preventive effects of weikang. Among which the rats were infused simultaneoualy with 20%weikang and 20%weimeisu solution at 2ml ev-ery other day during the inducing period; The second partwas used as the therapeutic group. Among whichthe rats were infused with 30%weikang and 30%weimeisu solution once every day for 4 weeksrespectivelyafter induced period. The histopathological changes were observed respectively at the end of the experiment.The rseults showed.that significant increase in the thickness of mucosa and PAS-AB positive musin werepresent in weikang groups when compared to those in model group. P< 0.01;The parietal cellnumbersperoxyntic gland also increased when compared to those in model group;P<0.05;The mucosal epithelial cell le-sionxwere significantly decreased in weikang group when compared to those in model group,P<0. 05. Thesedata demonstrated that weikang has a definite preventive and therapeutical effects on the experimen-talchronic gastritis in rats, Suchconclusion provied a strong experimental evidence for weikang on clinicaltreatment.
出处
《兰州医学院学报》
1996年第1期6-8,共3页
Journal of Lanzhou Medical College
关键词
慢性
胃炎
胃康
组织病理学
experimental gastritis
weikang
prevention
histopathological change.
