摘要
哺乳动物的受精过程是一个十分复杂的动态过程,在这一过程中,精子表面的膜蛋白发挥着重要作用。受精素α和β是精子表面的膜蛋白,也是精子表面的特异性抗原。研究发现小鼠和人的受精素基因分别位于5号和8号染色体,只在睾丸中特异性表达。受精素β在精子成熟前分布于整个头部,要在附睾成熟后受精素只分布于头后部区域。受精素β基因敲除的小鼠精子与卵细胞的结合能力明显下降,特异性抗体的抑制作用及合成肽竞争性抑制作用可以抑制精卵结合。受精素β通过去整合素与卵细胞表面的整合素结合,在精卵细胞的结合中发挥着重要的作用。精卵质膜的融合主要是由Izumo蛋白完成。
Mammlian fertilization is a very complicated dynamic process. In this course, the membrane protein of sperm plays an important role. Fertilin α and β are sp erm surface proteins and specific antigens. The genes o!/ertilin located on 5 and 8 chrosome in mice and human, only express specifically in testis. Fertilin β is present in the plasma membrane of the whole head of immature sperm, then becomes concentrated in the posterior head domain of maturesperm. The capacity of specifically will descend in fertilin β gene knockout mice. The specific antibody and synthetic peptide can inhibit sperm-egg binding. Fertilin β binds to integrin in the egg membrane by disintegrin. Fertilin plays an important role in sper-egg binding, and spermegg membran fusion is mainly mediated by Izumo protein.
出处
《动物医学进展》
CSCD
2006年第7期27-30,共4页
Progress In Veterinary Medicine
关键词
受精素
精卵结合
融合
作用
fertilin
sperm egg binding
fusion
effeet
