期刊文献+

精子抗原受精素β的研究进展 被引量:2

Progress in Researches on Sperm Antigen Fertilin β
下载PDF
导出
摘要 受精素 β是精子表面特异性抗原 ,主要通过其去整合素结构域在受精过程中发挥重要的生理功能。本文对受精素β的蛋白质结构、定位及在受精过程中的作用进行了综述 ,并提出受精素 β可作为免疫避孕疫苗研究中重要的靶分子 。 Fertilin β plays an important role in fertilization by its disintegrin domain as a sperm-specific antigen. This paper reviews its structure, localization and roles in fertilization, and suggests that fertilin β, as an important target antigen, has a very promising value in the development of human immunocontraceptive vaccine.
作者 张军 李彦锋
出处 《中华男科学杂志》 CAS CSCD 2004年第1期52-54,58,共4页 National Journal of Andrology
关键词 受精素β 精子 免疫避孕 疫苗 精子抗原 fertilin β fertilization immune contraception vaccine
  • 相关文献

参考文献16

  • 1Primakoff P, Hyatt H, Tredick-Kline J, et al. Identification and purification of a sperm surface protein with a potential role in sperm-egg membrane fusion [ J ]. J Cell Biol, 1987, 104 ( 1 ):141-149. 被引量:1
  • 2Jury JA, Frayne J, Hall L. The human fertilin alpha gene is nonfunctional: implications for its proposed role in fertilization [ J ].Biochem J, 1997, 321 (3) :577-581. 被引量:1
  • 3Vidaeus CM, Von Kapp-Herr C, Golden WL, et al. Human fertilin beta: identification, characterization, and chromosomal mapping of an ADAM gene family member[ J]. Mol Reprod Dev,1997,46(3) :363-369. 被引量:1
  • 4Gupta SK, Alves K, Palladino LO, et al. Molecular cloning of the human fertilin 3 subunit [ J ]. Biochem Biophys Res Commun, 1996, 224(2): 318-326. 被引量:1
  • 5Gupta S, Li H, Sampson NS, et al. Characterization of fertilin βdisintegrin binding specificity in sperm-egg adhesion [ J ]. Bioorg Med Chem, 2000, 8(4) :723-729. 被引量:1
  • 6Zhu X, Evans JP. Analysis of the roles of RGD-binding integrins,α4/α9integrins, α6 integrins, and CD9 in the interaction of the fertilin β (ADAM2) disintegrin domain with the mouse egg membrane[J]. Biol Reprod, 2002, 66(4) :1193-1202. 被引量:1
  • 7Zhu X, Bansal NP, Evans JP. Identification of key functional amino acids of the mouse fertilinββ ( ADAM2 ) disintegrin loop for cell-cell adhesion during fertilization [ J ]. J Biol Chem, 2000,275(11 ): 7677-7683. 被引量:1
  • 8Hunnicutt GR, Koppel DE, Myles DG. Analysis of the process of localization of fertilin to the sperm posterior head plasma membrane domain during sperm maturation in the epididymis [ J ].Dev Biol, 1997, 191 (1):146-159. 被引量:1
  • 9丁蓓蓓,蒋俶,蒋文珏,王健,高尔生,左嘉客,申庆祥.受精蛋白β在人精子表面的免疫组织化学定位[J].实验生物学报,2001,34(4):283-289. 被引量:4
  • 10Evans JP. Fertilin beta and other ADAMs as integrin ligands: insights into cell adhesion and fertilization [ J ]. Bioessays, 2001,23(7) :628-639. 被引量:1

二级参考文献4

共引文献3

同被引文献37

引证文献2

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部