摘要
精卵融合是有性生殖中最为关键的事件之一,因此对该过程分子机制的理解具有十分重要意义。已经发现多种蛋白质涉及到这个重要的过程,主要包括卵子表面的CD9、GPI锚定蛋白和整合素等,精子表面的附睾蛋白DE、Izumo和ADAM家族成员等,它们通过特异性的识别和结合而辅助完成了精卵融合。这些进展对开发新的用于生殖调节或不育诊断和治疗技术、药物提供了保证。
Sperm-oocyte fusion is one of the most key events in sexual reproduction, so it has an important significance to understand its molecular mechanism. There are several molecules that involved in sperm-oocyte fusion, such as CD9, glycosylphosphatidylinositol-anchored proteins and integrins on oocytes, and epididymal pro- tein DE, Izumo and ADAMs on sperm. These molecules assist to complete sperm-egg fusion by special recognition and binding. These progress has vital application in developing new methods for both fertility regulation and diagnosis and treatment of human infertility.
出处
《细胞生物学杂志》
CSCD
2007年第3期361-364,共4页
Chinese Journal of Cell Biology
关键词
精子
卵子
融合
sperm
oocyte
fusion
