摘要
2-苯乙胺、反式-4-甲基环己胺分别与三光气反应生成相应的异氰酸酯。2-苯乙基异氰酸酯与3-乙基-4-甲基-3-吡咯啉-2-酮加成(收率87.2%)后,经磺化、氨解(收率78.1%)得到的取代磺酰胺,再与反式-4-甲基环己基异氰酸酯反应得到格列美脲,收率75.1%。标题化合物总收率51.1%(以吡咯啉酮计),含量99.6%(反式)。
β-phenylethyl isocyanate and tran-1-isocyanato-4-methyl cyclohexane were prepared through reaction of β-phenylethylamine and trans-4-methyl clyclohexanamine with triphosgene, respectively. Addition of β- phenylethylisocyanate and 3-ethyl-4-methyl-pyrrolin-2-one to yield intermediate substituted sulfamide via sulfonation and amination, and then the substituted sulfamide was reacted with trans-1-isocyanato-4-methylcyelohexane to yield glimepiride with its overall yield and purity is of 51.1% and 99.6%, respectively.
出处
《精细化工中间体》
CAS
2006年第3期16-18,共3页
Fine Chemical Intermediates
