摘要
目的探讨沙鼠高脂血症与动脉粥样硬化的相关性。方法用含1%胆固醇+10%猪油+10%蛋黄粉的高脂饲料饲养沙鼠120 d,检测血清总胆固醇(TC),高密度脂蛋白胆固醇(HDL_c),低密度脂蛋白胆固醇(LDL_c),血清甘油三酯(TG)的变化,在120 d时处死动物,取各组织作形态学观察。结果高脂组沙鼠的TC、HDL_c、LDL_c的值一直都明显高于对照组,以LDL_c升高为主,且出现了严重的脂肪肝,肝硬化,脾脏肿大和主动脉根部粥样硬化。结论加重高脂血症的程度能导致长爪沙鼠形成动脉粥样硬化的病理改变,沙鼠可能是一种适合研究脂肪肝的实验动物。
Objective To analyze the correlation between hyperlipidemia and atherogenesis in gerbils. Methods Fourteen gerbils in the experimental group were fed with a diet containing 1% cholesterol, 10% lard and 10% yolk powder. Twelve gerbils in the control group were fed with normal chow. Serum total cholesterol, triglyeerides, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol of gerbils in the two groups were measured at the 0, 7th, 30 th, 60th, 90th and 120th day. Finally all the animals were sacrificed and examined by histopathology. Results Serum TC, LDL-c and HDL-c of gerbils in experimental group were much higher than those in the control group during the 120 days, with increased serum LDL-e concentration in particular. Fatty liver, hepatoeirrhosis, splenomegalia and aortic atherosclerosis were observed in the experimental group. Conclusion Aortic atherogenesis in gerbils can be promoted by hyperlipidemia. The gerbil might be used as a suitable laboratory animal for fatty liver research.
出处
《中国比较医学杂志》
CAS
2006年第6期321-324,I0001-I0002,共6页
Chinese Journal of Comparative Medicine
基金
北京市248工程科技重大项目(H020220050390)
