摘要
目的：综合评价DNA修复基因XRCC1（X-ray cross-complementing group 1）的399位点多态性同肺癌易感性的关系。方法：检索中国生物医学数据库和Medline，获得有关XRCC1基因399位点多态性同肺癌易感性关系的研究结果，并进行Meta分析。所有文献均采用病例对照研究，以非条件Logistic回归校正年龄、性别和吸烟状况等混杂因素后的OR值为效应指标，对文献进行评价筛选、异质性检验。利用Meta分析软件Rev Man 4．2对各研究原始结果进行统计处理，并计算合并OR值及其95％可信区间。结果：本次Meta分析共纳入15项研究，累计病例6818例，对照7610例。Arg／Gln和Gln／Gln等位基因同Arg／Arg比较，OR值分别为0．99（95％ CI：0．91～1．06）和1．04（95％ CI：0．92～1．17），Z值分别为-0．37和0．67，对应的P值分别为0．71和0．50。结论：尚无足够证据证明DNA修复基因XRCC1的399位点多态性同肺癌易感性有关。
OBJECTIVE： To evaluate the relationship between polymorphisms of XRCC1 （X-ray cross-complementing group 1） at Arg399Gln loci and lung cancer. METHODS： Literatures searched on CBM disk and Medline were enrolled in the Meta-analysis. The Meta-analysis was applied with Rev Man4.2 software for heterogeneity test and calculation of pooled OR value. RESULTS： Fifteen case-control studies with 6 818 cases and 7 610 controls were analysed by the fixed-effect meta-analysis method. The pooled OR values of Arg/Gln and Gln/Gln compared to Arg/Arg were 0.99 （95% CI： 0.91～1.06） and 1.04 （95% CI： 0.92～1.17）, Z statistics were -0.37 and 0.67, and their responding P values were 0.71 and 0.50. CONCLUSION： Although bias cannot be excluded, the findings suggeste that genetic polymorphism of XRCC1 DNA repair gene at Arg399Gln loci might not contribute to the susceptibility of lung cancer.
出处
《中华肿瘤防治杂志》
CAS
2006年第11期813-816,825,共5页
Chinese Journal of Cancer Prevention and Treatment
基金
国家自然科学基金资助项目(30471493)
