摘要
目的探讨X线修复交叉互补基因1(XRCC1)399位点多态性与肝细胞癌发病风险之间的关系。方法检索国内外数据库,获得有关XRCC1基因多态性与肝细胞癌发病风险的病例-对照研究资料,用Review Manager 4.2.8分析软件对纳入本项Meta分析的各研究数据进行综合统计处理及异质性检验,计算合并的OR值(95%CI)。结果符合纳入标准的共有7篇文献。累计肝细胞癌病例1133例,对照1747例。Meta分析结果显示,与野生基因型Arg/Arg相比,杂合变异基因型Arg/Gln和(Arg/Gln+Gln/Gln)合并的OR值(95%CI)均为1.00(0.68,1.47),纯合变异基因型Gln/Gln合并的OR值(95%CI)为1.02(0.60,1.72)。XRCC1 399位点多态性与肝细胞癌的发病风险之间的关系均无统计学意义。结论未发现XRCC1 399位点多态性与肝细胞癌发病风险之间的统计学相关性。
Objective Discuss the relationship between the X-ray repair cross complementing gene group 1（XRCC1） 399 point polymorphisms and risk of hepatocellular carcinoma occurrence.Methods Search the domestic and abroad database to obtain the related cases of XRCC1 gene polymorphisms and risk of hepatocellular carcinoma occurrence,and use the analysis software Review Manager 4.2.8 to perform the comprehensive statistic processing and heterogeneity test for each research data included in this meta analysis and calculate the combined OR value（with 95% CI）.Results There were 7 literatures conformed to the inclusion criteria.A total of 1133 hepatocellular carcinoma cases and 1747 control cases were included.The meta analysis results showed that compared with the wild-type homozygous Arg /Arg,the combined OR（95% CI） of variant heterozygous genotype Arg /Gln and（Arg /Gln ＋ Gln /Gln） were both 1.00（0.68,1.47）,and the combined OR（95% CI） of variant homozygous genotype was 1.02（0.60,1.72）.The relationship between XRCC1 399 point polymorphisms and the risk of hepatocellular carcinoma occurrence was of no statistical significance.Conclusion No statistically significant relationship between the genotype of XRCC1 399 point polymorphism and the risk of hepatocellular carcinoma occurrence was found.
出处
《卫生研究》
CAS
CSCD
北大核心
2010年第6期664-668,共5页
Journal of Hygiene Research
基金
国家自然科学基金面上项目(No.30872962)
