摘要
目的探索研究前S1抗原(PreS1-Ag)与原发性肝癌(PHC)发生的关系。方法对200例已确诊的肝癌患者及200例已确诊的非肝癌就诊者用ELISA法进行乙肝五项血清学标志物及PreS1-Ag检测。结果肝癌患者血清中HBsAg/AntiHBe(+/+)的百分率远大于HBsAg/HBeAg(+/+)的百分率,亦远大于PreS1-Ag(+)百分率;而非肝癌就诊者血清HBsAg/AntiHBe(+/+)的百分率也远小于肝癌患者。结论HBsAg/AntiHBe(+/+)能反映肝脏发生癌变的危险性增加。而血清PreS1-Ag在一定程度上反映病毒的活动性复制,可弥补HBV血清标志物在肝癌检测中的不足。
Objective To clarify the relationship between serological HBV markers （HBVM）, PreS1 - Ag and hepatocellular carcinoma （HCC）. Methods The 5 serological markers and PreS1 - Ag were examined and compared in 200 patients with HCC and 200 patients without HCC. Results Among the patients with HCC, the positive rate of both HBsAg and HBeAb was rruch higher than that of both HBsAg and HBeAg and that of PreS1 - Ag. Compared with patients without HCC, the positive rate of both HBsAg and HBeAb was obviously higher in the HCC patients. Conclusions It could be associated with an increased risk for the development of HCC when both HBsAg and HBeAb are positive; and PreS1 - Ag is also a marker of increased HCC risk in some extent.
出处
《实用预防医学》
CAS
2006年第3期752-753,共2页
Practical Preventive Medicine
