摘要
用前Ｓ１合成肽作试剂（抗原）建立一种酶免疫法，检测各型乙型肝炎病毒（ＨＢＶ）感染系列血清。前Ｓ１抗体检出率在急性乙型肝炎为１００％，慢性活动型肝炎８０％，无症状ＨＢＶ携带者３０％，前Ｓ１抗体在ＨＢｓＡｇ阴转、抗－ＨＢｅ血清转换之前和之后分别为１０．５％和５０％，有显著性升高。各型感染的前Ｓ１抗体检出率与血清丙氨酸转氨酶水平相关。结果提示：前Ｓ１抗体较常出现在肝脏炎症活动时，并在清除ＨＢＶ中增高。因此，前引抗体可反映肝细胞损伤和病毒清除。
In order to elucidate the clinical siginicance of anti-preS1 antibody,an enzyme immunoassay (EIA) was developed using a synthetic peptide analogue of presl protein as reagent antigen for testing a different categories of HBV infected patients.The prevalence of anti-preS1 was 100% in acute hepatitis B, 81% in chronic active hepatitis and 30% in asymptomatic HBV carriers,respectively. Anti-preS1 was detected in 10.5% of both HBsAg and HBeAg positive and 50% of anti-HBe-positive and HBsAg negetive asympotmatic HBV carriers,and it was statistically significant.The prevalence of anti-preS1 in AH and CAH were correlated with the increased levels of ALT.The results indicate that anti-preS1 is an earlier antibody of HBV infection.It more often appears in the above liver disease and increased during virus clearance.So,anti-preS1 may reflect both hepatocellular injury and HBV clearance.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
1994年第2期120-122,共3页
Chinese Journal of Experimental and Clinical Virology
关键词
前S1抗体
乙型肝炎病毒
感染
Anti-PreS1 antibody Hepatitis B virus infection
