摘要
目的观察血清GP73水平对HBV相关肝硬化的诊断价值。方法本研究共观察了接受乙肝穿刺的慢性乙肝患者200例；失代偿乙肝肝硬化患者200例；以及HBV相关肝癌（HCC）患者200例。所有患者均为连续入组的患者，所有患者血清HBsAg阳性持续均在6个月以上，符合慢性HBV感染的诊断。结果与慢性肝炎患者（67．38±57．45ng／ml）相比，肝硬化患者（221．9±108．5ng／ml）和HCC患者（152．44±102．7ng／ml）的血清GP73显著升高。以慢乙肝患者为对照人群，GP73诊断肝硬化的ROC分析曲线下面积为0．91（95％CI：0．88-0．94）（P〈0．0001）。以150ng／ml为诊断cut—off值，GP73诊断肝硬化的特异性和敏感性分别为72．5％和93．5％。结论HBV慢性感染患者，血清GP73显著升高，除考虑肝癌诊断外，还应该考虑肝功能失代偿的可能。
Objective To evaluate the role of serum GP73 for diagnosing decompensated cirrhosis in population with chronic HBV infections. Methods The present study included three populations： 200 patients with chronic HBV infections and receiving liver biopsy; 200 patients with decompensated cirrhosis; and 200 patients with hepatocellular carcinoma. All patients were HBsAg-positive over six months. Results Comparing with those in the patients with chronic hepatitis B （67.38 ± 57.45 ng/ml） , the serum GP73 levels in cirrhosis patients （221.9 ± 108.5 ng/ml） and HCC patients （ 152.4 ± 102.7 ng/ml） were significantly increased. Taken the population with chronic hepatitis B as ＂control group＂, the patients with decompensated cirrhosis as ＂patients group＂, the area of ROC analysis was O. 91 （95 % CI：O. 88-0. 94 ） （P 〈 0. 0001 ）. Set the cut-off value at 150 ng/ml, the diagnosing sensitivity and specificity were 72.5% and 93.5% , respectively. Conclusion For patients with chronic HBV infections and a higher GP73 levels, decompensated cirrhosis should be considered, except diagnosis of hepatocellular carcinoma.
出处
《中华实验和临床病毒学杂志》
CAS
CSCD
2014年第2期85-86,共2页
Chinese Journal of Experimental and Clinical Virology
基金
国家自然科学基金（81071411
81271901）
关键词
高尔基体
肝炎
乙型
慢性
肝炎病毒
乙型
肝硬化
肝肿瘤
Golgi apparatus, Hepatitis B, chronic
Hepatitis B virus
Liver cirrhosis
Liver neoplasms
