摘要
近两年，人们相继发现了一组能结合性抑制周期蛋白依赖激酶（ＣＤＫｓ）活性的蛋白因子──ＣＤＫ抑制因子（ＣＫＩｓ）。它们分别是：ｐ２１、ｐ１６、ｐ１５、ｐ２７和ＣＤＩｌ。ｐ２１和ｐ２７有一定同源性，能抑制多种ＣＤＫｓ的活性；ｐ１６和ｐ１５则同源性更高，能特异地与ＣＤＫ４、ＣＤＫ６结合；ＣＤ１１的结合特异性还有待进一步的研究。ｐ２１的表达受ｐ５３的正调控；ＴＧＦ－β则上调ｐ１５的表达以及ｐ２７的抑制活性。以上表明ＣＫｌｓ不仅是ＣＤＫｓ活性的调控者，而且还是抑癌因子与细胞周期调控之间的直接联系者。
In recent two years,a group of protein factors have been found to combine with the cyclin-dependent kinases(CDKs)and block the activation of cyclin/CDK complexes.They are named CDK inhibitors(<CKIs)as p21,p16,p15,p27 and CDI1.The p21 and p27 have certain homology and can inhibit the activity of multiple CDKs;p 16 and p15 have higher homology and can specifically combine with CDK 4 and CDK 6;and the combination specificity of CDI1 needs further research;The expression of p 21 is regulated positively by p5 3.TGF-βcan upregulate the expression of p 15 and the inhibitory activity of p2 7.The above findings demonstrate that CKls are not only the regulators of CDKs'activity but also the direct linkers between cancer inhibitors and cell-cycle regulation.
出处
《生理科学进展》
CAS
CSCD
北大核心
1996年第2期107-112,共6页
Progress in Physiological Sciences
关键词
哺乳动物纲
细胞
周期蛋白
依赖激酶
抑制因子
Cell-cycle regulation
Cyclin
Cyclin-dependent kinase
Cyclin dependent kinase inhibitor
