摘要
巨噬细胞是腹腔液中主要的有核细胞,是对炎症刺激发生反应的第一线细胞。子宫内膜异位症患者腹腔液增多,腹腔液中巨噬细胞浓度增加,腹腔液和血清中由巨噬细胞分泌的细胞因子也明显增多。巨噬细胞吞噬精子能力亢进,抑制精子的活动度及其功能;还可介导炎症反应引起盆腔粘连,改变盆腔正常的解剖结构,影响输卵管功能,从而导致不育。巨噬细胞分泌的一些细胞因子致胚胎毒性增加,但另一些细胞因子却对囊胚的形成具有促进作用。本综述着重从巨噬细胞及其分泌的细胞因子两方面来叙述巨噬细胞、子宫内膜异位症和不育三者之间可能的关系。
Macrophage is the main nucleated cell in the peritoneal fluid, and it is the first and main cell that reacts to the inflammation. In the endometriosis patients, the amount of peritoneal fluid and the concentration of macrophages are increased. Thus the cytokines secreted by macrophages in peritoneal fluid and serum are increased remarkably. The macrophage＇s ability of phagocytizing sperm may also be increased. Macrophages can inhibit the motility and function of sperm, change the anatomical structure of the pelvic by mediating the inflammation, affect the function of the oviduct, and induce infertility. Some cytokines secreted by macrophages could injury embryo, but others could improve the development of blastocyst. In this review, the relationship among macrophages, endometriosis and infertility was expatiated mainly with macrophages and the cytokines secreted by them.
出处
《生殖医学杂志》
CAS
2006年第2期141-144,共4页
Journal of Reproductive Medicine
