摘要
目的:探讨不同的MTX给药方法治疗异位妊娠后血清β-HCG下降速度、幅度及其影响因素。方法:回顾性分析保守治疗异位妊娠112例,其中48例采用肌肉注射MTX20 mg,共用药5 d为A组,35例MXT50 mg单次肌注为B组,29例采用超声引导下,病灶局部注射MTX20 mg为C组。治疗后定期监测血清水平直至正常。结果:A组40例血清低于5 000 IU/L完全治愈,另外8例血清β-HCG高于5 000 IU/L失败。B组32例治愈,3例失败而手术。C组29例全部治愈。C组治疗后血清β-HCG下降至正常,明显短于A、B组。保守治疗前血清β-HCG水平较高者,治疗后降至正常所需时间较长。结论:保守治疗异位妊娠后连续监测血β-HCG水平极为重要。输卵管局部注射MTX可提高异位妊娠保守治疗成功率。
Objeive： To analyze the reduetive rate, extent and influential factors of serum β-HCG levels after different conservative treatment for ectopic pregnancy. Methods： Using a retrospective cohort, we collected 112 cases that received conservative treatment for ectopic pregnancy, including 48 cases treated with MTX 20mg im qd × 5 （ group A）, 35 cases treated with single - dose of MTX 50mg in group B and 29 treated with local injection of MTX 20mg under the guidance of ultrasonography （ group C） The levels of Serum β- HCG was surveyed every three days after conservative treatment until Serum β- HCG titer return to normal. Results： 40 cases with Serum β- HCG levels less than 5 000 IU/L in group A cured completely, except 8 women with Serum β- HCG concentration higher than 5 000 IU/L All 29 women of group C and 32 of 35 women of group B healed so. 3 cases in group B developed and treated with surgery. The mean time for decline of serum β- HCG to normal levels was significantly shorter in group C than in group B and A. The kigher serum β-HCG titers before conservative treatment related with longer time that drop to normal. Conclusion： Consecutive surveillance of serum β-HCG titers after conservative treatment is very important. Fallopian local injection of MTX may develop the successful rate of conservative treatment for ectopic pregnancy.
出处
《中国妇幼保健》
CAS
北大核心
2006年第6期762-763,共2页
Maternal and Child Health Care of China
