摘要
目的:探讨保守治疗早期异位妊娠的几种方案。方法:将138例早期异位妊娠患者,根据不同治疗方案分4组治疗,比较各组治疗效果。结果:MTX组53例成功(96.4%),其中8例行第2次注射MTX(14.5%)。MTX+米非司酮(RU486)组42例成功(97.7%),其中8例行第2次注射MTX(18.6%)。介入组21例,均一次注射成功(100%),期待治疗组19例,成功率100%。血β-HCG水平>2000U/L者,第2次用药率高达37.5%。MTX组和MTX+RU486组疗效比较,差异无显著性(P>0.05)。结论:4种保守治疗方案对早期异位妊娠患者均有效;对血β-HCG水平在1000U/L以下且继续下降,包块<3cm者,可在医院密切观察暂不用药。血β-HCG水平>2000U/L者需第2次注射MTX的患者增多。
Objective： To investigate the different protocol for conservative treatment of early ectopic pregnancy. Methods： From Dec. 2001 to May. 2004,138 patients with eady ectopic pregnancy were analyzed retrospectively. According to treatment protocol,these patients were divided into four groups：55 cases treated with single 75 rng MTX intramuscular as MTX group,43 treated with single 75 rng MTX i.m.and oral RU 486 200 rng as MTX＋ RU 486 group,21 treated with artery embolization with MTX as DSA group, another 19 without any treatment as expectant group.Results：53 patients （96.3%） in MTX group and 42 patients （96.6%） in MTX＋ RU 486 group were totally cured after first dose of MTX, while there were 8 patients in MTX group （ 14.5% ） and 8 in MTX ＋ RU 486 group （18.6%）,respectively,that needed second dose of MTX for curing.21 patients （100%） in DSA group successfully were achieved one＇s aim by once time. 19 patients （ 100% ） in expectant group ware completely recovered also. The rates of repeated dosage given reached to 37.5 % in patients with β-HCG levels 〉 2000 U/L. There were no significant difference between MTX group and MTX ＋ RU 486 group in curative rates （ P 〉 0.05）. Conclusions： The four different treatment protocols were effective for patients with early ectopic pregnancy.When the β-HCG levels was 〈 1000 U/L or β-HCG titer gradually decreased,and the diameter of pelvic mess was 〈3 cm,the expectant therapy is suitable with close investigation in hospitalization. The chance that need second dose of medicine increase when serum β-HCG level 〉 2000 U/L.
出处
《实用妇产科杂志》
CAS
CSCD
北大核心
2006年第8期489-491,共3页
Journal of Practical Obstetrics and Gynecology
