摘要
胰腺十二指肠同源盒(PDX-1)具有促进胰岛β细胞增殖以及抑制其凋亡的作用。PDX-1通过调控胰岛素及胰岛素相关基因如葡萄糖激酶(GK)、葡萄糖转运蛋白(GLUT2)等的表达,促进胰岛素分泌,维持胰岛β细胞的正常功能。提高胰岛β细胞PDX-1蛋白表达量,可对抗因“糖毒性”所致的胰岛β细胞功能损伤,促进胰岛素基因表达。PDX-1还可以将非胰岛素分泌细胞如肝细胞等转化为胰岛素分泌细胞。
The pancreatic duodenal homeobox factor-1 （PDX-1） plays a central role in the regulation of pancreatic development and differentiation of insulin-secreting cells from progenitor cells. PDX-1 stimulates islet 15 cells growth, inhibits their apoptosis and maintains the pancreatic islet functions by activating transcriptions of genes including insulin, glucose transporter type 2, and glucokinase. It resists glucotoxicity-induced injury of 15 cells and restores normal insulin expression by increasing PDX-1 protein in β cells. Furthermore, PDX-1 is shown to be involved in the differentiation of non-insulin producing cells to β ceils.
出处
《国际病理科学与临床杂志》
CAS
2006年第1期55-58,共4页
Journal of International Pathology and Clinical Medicine
