摘要
受精过程中精卵质膜融合分子机制的研究一直备受关注。随着基因剔除技术的发展及众多新技术的应用,人们发现这一过程涉及多种分子,目前对卵膜上的CD9、糖基化磷脂酰肌醇锚定蛋白和整合素研究较多。现从细胞层次和分子层次上总结三者在精卵质膜融合方面的实验及结论,分析各个实验结果矛盾之处,讨论精卵质膜融合研究的前景。
The molecular mechanism of the sperm-oocyte plasma membrane fusion during fertilization has been investigated in recent years. Development of gene targeting and application of new technologies allow us to identify the molecules involved in fertilization processes. Recent studies are focusing on CD9, Glycosylphosphati- dylinositol-anchored proteins and integrins on oocyte surface. This paper summarizes the results and the related experiments on these three moleculesat at celluar and molecular levels.
出处
《细胞生物学杂志》
CAS
CSCD
2006年第1期33-36,共4页
Chinese Journal of Cell Biology
关键词
精卵质膜融合
CD9
糖基化磷脂酰肌醇锚定蛋白:整合素
sperm-oocyte plasema membrane fusion
CD9
glycosylphosphatidylinositol-anchored proteins
integrin
