摘要
目的探讨扣带回、海马以及额叶损伤患者的情绪认知特征,验证这些脑结构参与情绪加工以及恐惧的特异性神经机制的假说。方法分别测试双前额叶损伤12例、双海马损害1例(例1)、双前扣带回合并右杏仁核损害1例(例2)和对照组的被试者对表情面孔6种基本情绪(喜、惊、怕、悲、厌和怒)的辨认能力。结果与健康对照组比较,前额叶损害组患者的6种情绪辨别普遍受损(6种基本情绪的平均正确得分分别为18·41、16·58、11·08、15·67、12·92和15·33,P<0·01),例2表现为恐惧情绪的选择性辨别障碍(“怕”的正确得分为4·67,P<0·01),而有明显记忆障碍的例1之情绪辨别能力却正常。结论结果提示扣带回与杏仁核可能一起特异性地参与了恐惧情绪的加工,而双侧前额叶可能非特异性地参与了各种基本情绪的加工。海马结构主要参与情景记忆,可能并不参与情绪加工。
Objective To find out the profile of perception of emotion in patients with lesions in bilateral eingtdate gyms, bilateral hippocampus and prefrontal cortex, and to test which of these areas are involved in the special network of fear processing. Methods A six-basic-emotion continum with 30 morphed emotional faces across happiness-surprise-fear-sadness-disgnst-anger-happiness was developed. A labeling task with these morphed emotional faces was administered to measure the ability of recognizing the emotional expressions. Results A group of 12 eases with prefrontal lesions, showed a gross impairment of recognition of expressions across all 6 basic emotions （the correct scores for 6 basic emotions are 18.41,16.58,11.08, 15.67,12. 92 and 15.33 respectively, P 〈 0. 01 ）. Case 1 （with lesion in bilateral hippocampus） showed normal ability in recognizing all emotional faces, but an obvious impairment of episodic memory. Case 2 （with bilateral anterior cingnlate gyms lesions and a very small lesion in the right amygdale） manifested a robust deficit in recognition of fearful expressions （ the correct score for fear is 4. 67 ,P 〈 0. 01 in comparison with normal and schizophrenic controls） sparing other emotions except disgust processing （barely borderline different from normal controls）. Many cases had shown that unilateral lesion in the amygdala, whether left or right, was not enough to impair fear processing. Although case 2 had a very small lesion in the fight amygdala, the result of his performance suggested that bilateral cingnlate gyms, like bilateral amygdala, were selectively involved in fear processing. Conclusions It is suggested that bilateral amygdala and cingnlate gyms be all selectively involved in fear processing （ in parallel or at different levels ）, while the prefrontal cortex functions as unselective processor for processing of all emotions. It is also possible that hippocampus be involved in the episodic memory, but not in emotional process.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2005年第12期769-772,共4页
Chinese Journal of Neurology
基金
国家自然科学基金资助项目(30370479)
安徽省优秀青年科技基金资助项目(04043071)
国家教育部归国留学人员科研启动基金资助项目[(2003)14]
安徽省教育厅自然科学基金重点资助项目(2004kj192zd)
安徽省自然科学基金资助项目(01043602)
关键词
扣带回
杏仁核
额叶
情绪
Gyrus cinguli
Amygdala
Frontal lobe
Emotions
