摘要
目的探讨岛叶、基底节卒中患者的情绪认知特征,验证这些脑结构参与情绪加工以及厌恶的特异性神经机制的假说。方法测试2例岛叶损伤患者(例1、例2)、32例基底节卒中患者(基底节梗死或出血)和30名健康对照组的6种基本情绪(喜、惊、怕、悲、厌、怒)和中性情绪的面孔表情以及声音辨认能力。结果与相应对照组比较(厌恶面孔和厌恶声音的正确得分为14.65±2.25、17.61±3.12),例1、例2对厌恶声音和厌恶面孔的辨别均有障碍(厌恶面孔识别正确得分分别为7、9,厌恶声音识别正确得分分别为7、8,P<0.01)。而基底节卒中患者主要表现厌恶面孔辨别障碍(正确得分为10.42±2.71,P<0.01),对厌恶声音辨别正常,但表现为“怕”和“怒”的辨别障碍(正确得分为11.00±2.31、13.30±2.75,P<0.05)。结论基底节可能选择性参与厌恶情绪的视觉加工,而岛叶则选择性参与了厌恶情绪视觉和听觉通道的加工。岛叶-基底节系统在厌恶情绪加工中起着重要作用。
Objective To find out the profile of perception of emotion in patient with lesions in left insular, basal ganglia, and test the hypothesis that these brain regions are involved in the special network of disgust processing. Methods We developed a neuropsychological battery of faces and voices representing six-basic-emotion. A labeling task with facial and vocal emotion measured the ability to recognize basic emotions. Results Two patients with insular lesions （one in the left, the other in the right） , manifested a substantial inability in recognizing disgust （the correct scores for expressions being 7,9 ,and for voice 7, 8, P 〈 0. 01 in comparison with normal controls）. Patients with stroke in basal ganglion impaired their perception of facial emotions of disgust and surprise （respectively, correct identification scores 10. 42 ± 2. 71,15.09 ± 2.08 ; P 〈 0. 01, P 〈 0. 05 ）. Their scores for disgust were worse than those for surprise （ P 〈 0. 01 ）. But they normally perceived vocal emotion of disgust （ Z = 2.48, P 〉 0. 05 ）. Conclusion The severe deficit of disgust in patients with lesion in insular and basal ganglia supported that insular-basal ganglia system may play an important role in disgust processing.
出处
《中华神经科杂志》
CAS
CSCD
北大核心
2006年第10期655-658,共4页
Chinese Journal of Neurology
基金
安徽省自然科学基金资助项目(01043602)
安徽省优秀青年科技基金资助项目(04043071)
国家自然科学基金资助项目(30370479)
国家教育部归国留学人员科研启动基金资助项目([2003]14)
安徽省教育厅自然科学基金重点资助项目(2004kj192zd)
关键词
基底神经节
情绪
认知障碍
神经心理
Basal ganglia
Emotions
Cognition disorders
Neuropsychology
