摘要
目的:检测侵袭性牙周炎(AgP)龈沟液中白细胞介素(IL-8)的总量和浓度并探讨其与牙周临床指标的关系。方法:采用常规滤纸条法收集侵袭性牙周炎实验组患牙(T1)和健康牙(T2)各位点及正常对照组(C)各位点的龈沟液(GCF)样本,用ELISA法检测各样本中IL-8的总量和浓度。结果:3组受检牙龈沟液中IL-8的总量和浓度不同。侵袭性牙周炎患牙组GCF中IL-8总量高于健康牙位组(P<0.05)及正常对照组;而3组中IL-8浓度差异也有显著性,侵袭性牙周炎患牙组GCF中IL-8的浓度高于健康牙位组(P<0.05)和正常对照组;虽然GCF中IL-8浓度与牙周探诊深度(PD)、牙龈出血指数(BOP)、附着丧失(AL)无相关关系;但IL-8总量与以上牙周临床指标相关。结论:在侵袭性牙周炎患者龈沟液中IL-8是参与牙周炎症反应的重要调节因子。
Objective： To detect the amount and concentration of intedeukin -8 in the gingival crevicular fluid （GCF） from aggressive periodontitis（AgP） and to evaluate the relationships between aggressive periodontitis and clinic periodontal parameters. Methods： Following careful sampling of GCF with standardized filter strips in healthy control prosition sites and periodontitis position sites from AgP and healthy subjects, the levels of interleukin - 8 were detected by ELISA technique. Results： The Interleukin -8 amount of GCF among three groups was significantly different. The Interleukin -8 amount of GCF in aggressive periodontitis（AgP） inflamed groups was significantly higher than those of healthy groups from aggressive periodontitis（AgP） （P 〈 0. 05 ）and healthy control groups; The concentration among them were also significant different. The Interleukin -8 concentration of GCF in aggressive periodontitis（AgP） inflamed groups was significantly higher than those of healthy groups from aggressive periodontitis （ AgP ） （ P 〈0. 05 ） and healthy control groups. There were no correlations between IL- 8 concentration and bleeding on probing（BOP） , probing depth（PD） and attachment loss（ AL）, but there had significantly positive correlations between IL - 8 amounts and bleeding on probing （ BOP ）, probing depth （PD） ,attachment loss（AL）. Conclusions： These results suggest that IL -8 may play an important role in pathogenesis of aggressive periodontitis.
出处
《口腔医学研究》
CAS
CSCD
2005年第6期612-614,共3页
Journal of Oral Science Research
基金
深圳市卫生科技计划项目基金资助(编号:2000004608)
