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人血管内皮细胞中腺苷代谢的定量研究 被引量:5

人血管内皮细胞中腺苷代谢的定量研究
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摘要 目的:通过对人脐静脉内皮细胞腺苷分泌进行定性及定量研究,了解人类血管内皮细胞的腺苷代谢及机制。方法:收集并测定不同干预下细胞柱流出液中分离的人脐静脉内皮细胞分泌的腺苷量。结果:在无干预、抑制腺苷激酶及去氨酶、抑制细胞膜腺苷转运情况下,人脐静脉内皮细胞腺苷分泌率分别为13.5±7.1 pmol.min-1.mg?-1、32.5±14.2 pmol.min-1.mg-1和20.8±15.7 pmol.min-1.mg-1。结论:人类血管内皮细胞内腺苷合成高于胞外,而细胞膜腺苷转运被抑制后的腺苷分泌率反而高于生理状态下分泌率,则表明腺苷在胞内分解代谢非常迅速,使部分腺苷反由胞外扩散入胞内。
出处 《中国应用生理学杂志》 CAS CSCD 北大核心 2005年第4期440-442,共3页 Chinese Journal of Applied Physiology
关键词 人血管内皮细胞 腺苷 代谢 human endothelial cells adenosine metabolism
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参考文献5

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同被引文献23

  • 1向邦德,吕明德,黄洁夫,汤庆.诱导正常血管内皮细胞具备肿瘤血管特性的研究[J].中山大学学报(医学科学版),2005,26(3):354-357. 被引量:10
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