摘要
目的评价复方苦参注射液对中晚期肺鳞癌化疗患者免疫功能的影响及其在化疗中的辅助作用。方法118例中晚期肺鳞癌化疗患者随机分为治疗组60例及对照组58例,常规化疗,治疗组加用复方苦参注射液20 mL,每日1次,共2周。观察治疗前、后两组患者T淋巴细胞和NK细胞的变化情况以及化疗后毒性反应。结果治疗组Karaufsky评分提高率明显高于对照组;治疗组CD3+、CD4+、CD4+/CD8+和NK细胞均值均有不同程度的提高,与对照组相比有显著差异(P<0.01);治疗组骨髓抑制和胃肠道反应均较对照组轻,且恢复快。结论复方苦参注射液能提高患者机体免疫功能,减轻化疗毒副反应。
Objective To evaluate the effect of Fufangkushen Injection （FI） on immunity of patient with metaphase and late lung squamous carcinoma treated with chemotherapy and FI＇ s assistant role in chemotherapy. Methods To divide randomly 118 patients with metaphase and late lung squamous carcinoma treated with chemotherapy into the treatment group （n = 60） and the control group （n = 58 ）. The control group was given the routine treatment and the treatment group was given chemotherapy and 20ml of FI once a day for two weeks. The changes of T cells and NK cells, and the side effects of chemotherapy were observed before and after the treatment. Results In the treatment group Karaufsky score was higher than that of the control group. The average index of CD3^＋, CD4^＋ ,CD4^＋/CD8^＋ and NK cells was increased in different degrees in the treatment group with a significant difference compared with the control group （P 〈0.01 ）. In the treatment group the side effects, like myelosuppression and gastrointestinal reaction were less serious, and the recovery time of the patient was shorter than that of the control group. Conclusion FI can improve the immunity of the patient and attenuate the side effects of chemotherapy.
出处
《北京中医药大学学报》
CAS
CSCD
北大核心
2005年第6期77-79,共3页
Journal of Beijing University of Traditional Chinese Medicine
基金
陕西省中医药管理局科研基金项目(No.2003-148)
关键词
苦参注射液
免疫功能
肺癌
化疗
Fufangkushen Injection
immunity
lung cancer
chemotherapy
