摘要
目的通过猴偏侧帕金森病(Parkinson disease,PD)模型丘脑底核(subthalamic nucleus,STN)脑深部电刺激(deep brain stimulation,DBS)系统的植入,对脑深部电刺激动物模型的制备进行了探讨。方法2只猴偏侧PD模型,按照猴脑立体定向图谱,在右侧STN植入脑深部刺激电极,并同期皮下植入脉冲发生器。术后行头颅X线平片和MRI检查,给予慢性高频电刺激,观察运动症状改善。结果2只偏侧猴PD模型成功的同期植入DBS系统,术后的症状观察和阿朴吗啡(apomorphine,APO)诱发旋转实验,证实STN慢性高频电刺激有效地缓解了猴PD样症状。结论通过立体定向技术同期将DBS系统植入动物体内,可以有效的建立DBS动物模型,为DBS在神经疾病的应用研究提供了良好的实验模型。
Objective To investigate the establishment of animal models of deep brain stimulation （DBS） by implanting the system of DBS in right subthalamic nucleus（STN）of hemiparkinsonian monkeys. Methods Two hemiparkinsonian monkeys were implanted with DBS leads in right STN according to stereotaxic atlas of the monkey brain. The pulse generators were implanted subcutaneouly in back of monkeys simultaneously. The examination of MRI and X plain film, regulation of stimulation parameters and the examination of behavioral effects of DBS were performed after surgery. Results Two hemiparkinsonian monkeys were implanted with DBS systems successfully. Behavioral observation and APO-induced rotation test indicate that PD symptoms of monkeys significantly improved after chronic high frequency stimulation of STN. Conclusion Animal models of DBS can be established by the system of DBS including of leads and pulse generators implanted simultaneously in animal models, which are important tools in experimental research of neurological disorders treated by DBS.
出处
《立体定向和功能性神经外科杂志》
2005年第5期283-286,共4页
Chinese Journal of Stereotactic and Functional Neurosurgery
基金
国家自然科学基金项目(编号:30471776)
关键词
脑深部电刺激
动物模型
猴
帕金森病
丘脑底核
Deep brain stimulation
Animal model
Monkey
Parkinson disease
Subthalamic nucleus
