摘要
实验性脑缺血时血小板醣化蛋白（ＧＭＰ－１４０）比对照组有显著升高，随缺血时间延长，ＧＭＰ－１４０呈渐进性升高，至缺血２４ｈ有显著下降，但ＴＸＢ２仍然呈升高趋势；缺血急性期的神经元及微血管循环障碍的病理变化与ＧＭＰ－１４０的演变过程有相关性，随水肿及循环障碍改善，ＧＭＰ－１４０显著下降，而ＴＸＢ２２４ｈ后仍然呈增高改变。结果表明急性脑缺血时ＧＭＰ－１４０的升高原因仅可能与血小板激活后的分解有关。它的动态变化趋势与急性循环损害的相关性表明ＧＭＰ－１４０在内皮依赖性血管舒缩障碍中有一定的意义，而ＴＸＢ２则受血小板在内的多种因素影响。
The result was suggested that GMP-140 on exiperimental group were significantly increaser than with control group.The increase of GMP-140 was continously in vary time after experimental ischemia,and there was significantly droped at 24th hour,but TXB2 was containly raised.We believed that the increase of GMP-140 in ischemia rabbit was mainly related with platelet lesions.It's changes has importantal value in diagnosing and treatmenting of acute stroke.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
1996年第2期81-82,共2页
Journal of Apoplexy and Nervous Diseases
