摘要
实验大鼠分为颌下腺切除＋ＣＣｌ_４组，假手术＋ＣＣｌ_４对照组及正常对照组。结果假手术＋ＣＣｌ４第２６时Ⅲ带细胞轻度受损，第４ｄ、８ｄ时受损面积略大，第１２ｄ时大部分细胞恢复；而颌下腺切除＋ＣＣｌ４组则损伤明显，第８ｄ时胞质极度稀疏，１２ｄ时大部分细胞尚未恢复，与假手术组比较，该组Ｆｅｕｌｇｅｎ反应略弱，ＰＡＳ反应减弱，第４～８ｄ时较明显，Ｇ一６一Ｐ，ＳＤＨ活性均减弱。结果表明颌下腺切除导致内源性表皮生长因子缺乏，影响ＣＣｌ_４所致肝损伤的修复。提示颌下腺的某些生物活性物质参与肝细胞损伤后的修复、再生。
adult rats were divided into three groups:(1) extirpation of submandibulargland group injected with CCl4,(2 ) sham-operation group injected with CCl4 and(3)normal control group. In the sham-operation group,only light fatty degenration was ob-served. While in the extirpation group,especially on the 8th day after operation, hepato-cytes showed very remarkable fatty degeneration. PAS stainingannshowed a decrease in glycogen content of hepatocytes in the extirpationgroup, while in very obvious from 4th to 8th days. The reactions of Feulgen,G一6一Paswell as SDH in this group were all weaker than those in the sham-operation group.The re-sults showed that the lack of endogenous EGF(epidermal growth factor) caused by extir-pation of submandibular gland could affect liver recovery, and it is also suggested that somebiologically active polypeptides, especially EGF, in submandibular gland are closely relatedwith regeneration and reparation of liver.
出处
《宁夏医学院学报》
1996年第1期8-10,共3页
Journal of Ningxia Medical College
关键词
肝损伤
颌下腺
组织学
四氯化碳
hepatic damage
submandibular gland
histology
histocytochemistry
rats
car-bon tetracchloride
