摘要
本研究应用从小鼠Ｓ１８０癌性腹水分离诱导的ＴＬ瘤内注射与活的双歧杆菌腹腔内注射共同治疗荷Ｓ１８０实体瘤小鼠，结果表明单用ＴＩＬ和ＴＩＬ合用ＩＬ－２早期抑瘤效果，能延缓肿瘤的发生和发展，而晚期抑瘤效果尚不及单用双歧杆菌组。ＴＩＬ与双歧杆菌、ＴＩＬ、双歧杆菌及低剂量ＩＬ－２，荷瘤早、晚期抑瘤效果均较好，且毒副作用低，表明双歧杆菌有可能通过刺激机体产生内源性ＩＬ－２维持ＴＩＬ的生物学活性从而协同ＴＩＬ细胞在体内的杀瘤作用。本研究亦表明ＴＩＬ中以ＣＤ＋细胞为主，杀瘤活性有一定的ＭＨＣ限制。
In this study,bifidobacterium combined with TILs(tumorinfiltrating lympho-cytes)induced from S180 carcinomic was used to trest mice bearing S180 solid tumor. Bifidobac-teria were given intraperitoneally, TILs were injected into tumor-attacking position local-ly. It found that in early period, TILs ,TILs combined with IL-2 exhibited good anti-tu-mor effect,retarding tumor incidence and development;while in advanced period ,their anti-tumor were inferior to that of bifidobacteria. We also found that TILs with bifidobacteria,TILa bifidobacteria with small dose of IL-2(100/mouse)exhibited excellent anto -tumor effect in both early and advanced periods
出处
《中国微生态学杂志》
CAS
CSCD
1995年第4期11-14,共4页
Chinese Journal of Microecology
基金
铁道部科技基金
关键词
肿瘤
免疫疗法
双歧杆菌
TIL细胞
白细胞介素
Bifidobacterium TILs(tumor infiltrating lymphocytes)IL-2(interleukin-2)
