摘要
对47名接触铬尘平均9年的工人进行系统调查,发现除皮肤、粘膜受损和X 线胸片异常等临床症状外,尿lys、尿β_2-MG 和尿蛋白明显升高、GFR 下降;体内铬负荷水平明显升高.尿铬既可反映体铬负荷水平,又可作为慢性铬中毒性肾损害的检测指标.铬与肾损害间存在时间效应关系.尿lys 与尿β_2-MG 相关密切,可用尿lys 代替尿β_2-MG 测定,并可作为早期检测铬性肾损害的指标.
47 workers exposed to chromate for an average of 9 years were investigated.It wasfound that not only the skin,mucous membrane of respiratory tract were damagedshowing abnormal features on X-ray films of chest,but also an apparent increase oflysozyme,β_2-microglobulin and protein in urine,a decrease of GFR.increase ofChromium level in the body were also evident.Chromium concentration in urinemay reflect the chromium level in the body.and serve as a criterion for the detectionof renal damage induced by chromium.There was a time-response relationship be-tween chromium and renal damage,and because of the close relation betweenlysozyme concentration and β_2-microglobulin concentration in urine,estimation oflysozyme concentration in urine instead of β_2-microglobulin can be used as an alter-native for the early detection of renal damage induced by chromate.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
1989年第4期197-199,共3页
Chinese Journal of Industrial Hygiene and Occupational Diseases
关键词
铬
肾功能
铬尘
职业病
铬负荷
Workers Exposed to Chromate
Chromium Toxicity
Renal Function
