摘要
在亚慢性铬中毒性肾损害动物模型研究发现：当血铬在６．６ｍｇ／ｍｌ以下时血铬与尿铬排泄率和肾铬水平呈明显正相关；当血铬超过６．６ｍｇ／ｍｌ时，尿铬排泄率开始下降，肾铬水平无明显增加。尿Ｌｙｓ、尿蛋白和ＧＦＲ出现异常的尿铬临界浓度分别为５．９０、７．５７和９．３６ｕｇ／ｍｇ肌酐。尿Ｌｙｓ和尿蛋白出现异常的肾皮质铬临界浓度分别是３６．７ｐｐｍ和４１．８ｐｐｍ。
Through the animal model of subchronic chromium induced renal damage,it was found as following:there were significant positive relationships between concentration of blood chromium and flowing rate of urinary chromium or concentration of renal chromium when blood chromium level belowed 6.6mg/ml.When blood chromium level was over 6.6mg/ml,flowing rate of urinary chromium declining,renal chromium without significant increasing.The critical concentrations of urinary chromium for urinary Lys,protein and GFR were 5.90,7.57 and 9.36μg/mg.cr respectively.The critical concentartions of renal cortex chromium for urinary Lies and protein were 36.7 and 41.8ppm respectively.
出处
《实用预防医学》
CAS
1994年第2期71-73,共3页
Practical Preventive Medicine
关键词
铬负荷
铬中毒性肾损害
动物模型
chromium load chromium induced renal damage animal model
