摘要
观察３７例青紫型先天性心脏病（ＣＣＨＤ）患儿的血栓弹力图（Ｔｈｒｏｍｂｅｌａｓｔｏｇｒａｍ，ＴＥＧ）、血小板聚集功能和血粘度等血液流变学参数的变化。结果显示：重度青紫组与对照组比较，ＴＥＧ的γ值、ｋ值和ｍ值显著延长，α角、ｍ_α值和ε值显著减小（Ｐ＜０．０１）：血小板聚集率显著降低（Ｐ＜０．０１），血小板计数和纤维蛋白原减少（Ｐ＜０．０５）；红细胞压积和全血粘度显著增高（Ｐ＜０．０１）；高、低切变率全血粘度与ＴＥＧ的ε值呈显著负相关，相关系数分别为－０．５７和－０．６４（Ｐ＜０．０５、＜０．０１）。结论：重度ＣＣＨＤ患儿具有显著的凝血机能障碍和血液流变学异常，血粘度越高凝血机能越低。
This paper presents 37 cases of cyanotic congenital heart disease in whom the change of hemorhologic parameters including the thrombelastorgram(TGE), platelet aggregation, blood viscosity were investigated. The comparison between severe cyanotic group and the control group showed that the γ value, k value and m value of TEG were prolonged (P<0.01), and the alpha angle, m_(α) value and ε value of TEG were significantly decreased (P<0.01). The platelet count and the fibrinogen decreased(P<0. 05)and the hematocrit and the blood viscosity were increased significantly. The blood viscosity in high and low shear rate were negatively correlated with value e of TEG, the coefficients were -0. 57 and -0. 64 respectively. It is concluded that patients with severe cyanotic congenital heart disease have serious disorder of blood coagulation and abnormality of blood viscosity. The higher of the viscosity, the lower the coagulation function.
出处
《同济医科大学学报》
CSCD
北大核心
1995年第1期26-28,共3页
Acta Universitatis Medicinae Tongji
关键词
先天性心脏病
心脏缺损
血液凝固障碍
儿童
发绀
heart defect
congenital
cyanosis
disorder of coagulation
viscosity of blood
thrombelastography
