摘要
目的探讨左旋门冬酰胺酶(L-ASP)对急性淋巴细胞性白血病(ALL)病儿凝血功能的影响及处理对策。方法对68例急性淋巴细胞白血病病儿分别于使用L-ASP前后对血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、抗凝血酶(AT)、纤维蛋白原(Fg)及D-二聚体进行检测。结果L-ASP治疗8 d后,所有病儿均出现血浆PT及APTT延长,Fg及AT活性降低、D-二聚体升高,与L-ASP治疗前相比较,有显著性差异(t=3.67-20.44,P〈0.05、0.01)。采取特殊干预措施,可以帮助提高临床治疗效果。结论L-ASP可引起ALL病儿的凝血异常,对其可能引发出血、血栓形成进行干预是有效的。
Objective To discuss the effect of L-asparaginase (L-ASP) on coagulation function and its management in children with acute lymphoblastic leukemia (ALL). Methods Prothrombin time (PT), activated partial thromhoplastin time (APTT), antithrombin (AT), fibrinogen (Fg), and D-dimer were detected before and during treatment hy LASPin 98 children with ALL. Results Eight days after L-ASP therapy, all the children showed prolonged PT and APTT, decreased activity of Fg and AT, and high level of D-dimer, the parameters above were significantly different as compared with that before therapy (t= 3.67-20.44;P〈0.05,0.01). Special intervention can improve the treatment. Conclusion LASP may cause abnormal coagula tion function in ALL children, intervention is effective to prevent possible bleeding and throm.
出处
《齐鲁医学杂志》
2008年第1期16-17,共2页
Medical Journal of Qilu