期刊文献+

左旋门冬酰胺酶对急性淋巴细胞性白血病病儿凝血功能的影响及处理对策 被引量:7

THE EFFECT OF L-ASP ON COAGULATION FUNCTION AND ITS MANAGEMENT IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA
下载PDF
导出
摘要 目的探讨左旋门冬酰胺酶(L-ASP)对急性淋巴细胞性白血病(ALL)病儿凝血功能的影响及处理对策。方法对68例急性淋巴细胞白血病病儿分别于使用L-ASP前后对血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、抗凝血酶(AT)、纤维蛋白原(Fg)及D-二聚体进行检测。结果L-ASP治疗8 d后,所有病儿均出现血浆PT及APTT延长,Fg及AT活性降低、D-二聚体升高,与L-ASP治疗前相比较,有显著性差异(t=3.67-20.44,P〈0.05、0.01)。采取特殊干预措施,可以帮助提高临床治疗效果。结论L-ASP可引起ALL病儿的凝血异常,对其可能引发出血、血栓形成进行干预是有效的。 Objective To discuss the effect of L-asparaginase (L-ASP) on coagulation function and its management in children with acute lymphoblastic leukemia (ALL). Methods Prothrombin time (PT), activated partial thromhoplastin time (APTT), antithrombin (AT), fibrinogen (Fg), and D-dimer were detected before and during treatment hy LASPin 98 children with ALL. Results Eight days after L-ASP therapy, all the children showed prolonged PT and APTT, decreased activity of Fg and AT, and high level of D-dimer, the parameters above were significantly different as compared with that before therapy (t= 3.67-20.44;P〈0.05,0.01). Special intervention can improve the treatment. Conclusion LASP may cause abnormal coagula tion function in ALL children, intervention is effective to prevent possible bleeding and throm.
出处 《齐鲁医学杂志》 2008年第1期16-17,共2页 Medical Journal of Qilu
关键词 左旋门冬酰胺酶 白血病 淋巴细胞 急性 血液凝固障碍 Lasparaginase Leukemia, lymphocytic, acute Blood coagulation disorders
  • 相关文献

参考文献8

二级参考文献10

  • 1Mitchell LG,Andrew M,Hannna K,et al.Determining the prevalence of thrombotic events in children with acute lymphoblastic leudemia and a central venous line who are treated with L-asparaginase:results of the prophylactic antithrombin replacement in kids with acute lymphoblastic leukemia treated with asparaginase(PARKAA) study[J].Cancer,2003,15,97(2):508-516. 被引量:1
  • 2Wrobel G,Dobaczewski G,Kazanowska B,et al.Adverse reactions associated with the use of L-asparaginase during therapy of patients with nB non-Hodgkin's lymphoma.Report of the polish paediatric leuKaemia/lymphoma study group[J].Med Wieku Rozwoj,2000,4 (suppl 2):S67-S72. 被引量:1
  • 3Mitchell LG,Halton JM,Vegh PA,et al.Effect of disease and chemotherapy on hemostasis in children with acute lymphoid leukenia[J].Am J Pediatr Hematol Oncol,1994,16(2):120-126. 被引量:1
  • 4Mauz-Korholz C,Nurnberger W,Irsfeld H,et al.Low rate of severe venous thromboses in children with ALL treatment according to COALL-92 and-97 protocol[J].Klin Pediatr,1999,211(4):215-217. 被引量:1
  • 5S. Sica,L. Pagano,P. Salutari,A. Mario,S. Rutella,G. Leone. Acute parotitis during induction therapy includingl-asparaginase in acute lymphoblastic leukemia[J] 1994,Annals of Hematology(2):91~92 被引量:1
  • 6M. Murakawa,T. Okamura,T. Shibuya,M. Harada,T. Otsuka,Y. Niho. Use of a synthetic protease inhibitor for the treatment ofl-asparaginase-induced acute pancreatitis complicated by disseminated intravascular coagulation[J] 1992,Annals of Hematology(5):249~252 被引量:1
  • 7张永红,赵新民,耿兰增.与左旋门冬酰胺酶治疗相关的低蛋白血症3例[J].白血病,1998,7(4):242-243. 被引量:10
  • 8顾龙君,孙桂香,卢新天,汤静燕,吴敏媛.小儿急性淋巴细胞白血病诊疗建议(第二次修订草案)[J].中华儿科杂志,1999,37(5):305-307. 被引量:304
  • 9杨双,石慧文,吴敏媛,段渊,张永红,耿兰增,赵新民,胡亚美.门冬酰胺酶治疗儿童淋巴系统恶性肿瘤的严重并发症[J].实用儿科临床杂志,2003,18(6):430-432. 被引量:3
  • 10孙黎明,支文靖,武万水,唐泓,张蕾,王起风,李苗.急性淋巴细胞白血病患儿大剂量静脉滴注门冬酰胺酶治疗后脑脊液门冬酰胺浓度[J].实用儿科临床杂志,2004,19(1):30-32. 被引量:3

共引文献331

同被引文献38

引证文献7

二级引证文献32

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部