摘要
目的探讨18F-脱氧葡萄糖(FDG)PET/CT显像在恶性肿瘤治疗中的临床价值。方法选取行18F-FDGPET/CT显像、最终经病理检查或临床诊断为恶性肿瘤(除脑肿瘤外)的患者96例,所有患者检查前未进行抗癌治疗。采用美国GEDiscoveryLSPET/CT仪,在PET/CT扫描床上进行CT模拟定位,指导勾画放射治疗靶区。用SPSS10.0软件进行统计学处理。结果①18F-FDGPET/CT检查的灵敏度为97.92%;PET/CT检查后45.83%的患者肿瘤分期发生了改变;淋巴转移与脏器和(或)其他转移分别增多了37.50%和23.96%。②PET/CT检查后36.46%的患者改变了原治疗方案。③PET/CT融合图像显示肿瘤的大小、边界及与周围组织结构的关系清楚,能为放疗准确提供生物靶区定位,为外科手术提供切除范围,临床随访效果满意。结论PET/CT可用于肿瘤的早期诊断、准确分期和协助制定治疗方案,指导放射治疗生物靶区定位和确定手术切除范围。
Objective To investigate the clinical value of PET/CT for the management of malignant tumors. Methods 96 patients（68 male, 28 female, mean age 61.7, ranged 26 - 89 years old）. All are confirmed by pathology or clinic ally except brain tumor and all were not treated. PET/CT imaging was performed using GE Discovery LS PET/CT. Radiotherapy target definition ： gross target volume （ GTV ） was defined using PET/CT fusion imaging. All data were analyzed with SPSS 10.0. Results ①Of 96 patients, PET/CT detection sensitivity was 97.92%. The overall tumor staging was changed in 44 （45.83%） patients and the rates of metastasis to the lymph nodes and other organs were increased 37.50% and 23.96% , respectively. ②The therapy regimen was changed in 35 （36.46%） patients after PET/CT imaging. ③The size, boundary and surrounding tissue of the tumor were clearly delineated in the fusion image. Henee it was possible for localization of biological target volume in radiotherapy and also for assessment of the reseeted extent for surgery. Conclusion PET/CT plays an important role in early diagnosis, accurate staging and management of tumor patients, especially as a guide to localization of the target volume in radiotherapy and assessment of the reseeted tumor extent during operation.
出处
《中华核医学杂志》
CAS
CSCD
北大核心
2005年第4期219-221,i0004,共4页
Chinese Journal of Nuclear Medicine
