摘要
凝集素与细胞膜上蛋白质结合对膜蛋白和膜脂的结构产生影响。本文研究ＣｏｎＡ与人红细胞膜蛋白结合下膜蛋白构象和运动变化及膜脂非双层转变。结果表明膜蛋白的α螺旋减少，膜蛋白分子的运动变化，膜脂分子出现非双层。说明配基与膜蛋白相互作用发生膜蛋白构象改变的同时导致膜脂多型性变化。
he effects of lectin-membrane protein interaction will
influence the structure of protein and lipid in membra-ne.In this
paper, the conformation and molecular dynamics of membrane protein
and the polymorphism of mem-brane lipid of human erythrocytes were
studied under the action of Con A with membrane protein.The results
ofCD showed that the α-helix structure of membrane proteins declined
in correspondence with the amounts of Con A.The time-resolved
fluorescence study also indicated the lifetime of membrane proteins
changed when Con A com-bined with membrane.The 31PNMR spectra showed
that Con A could induce the formation of nonbilayer structureof
membrane lipid which was related to the conformation change of
membrane protein.
出处
《北京医科大学学报》
CSCD
1995年第4期261-263,共3页
Journal of Peking University(Health Sciences)
基金
国家自然科学基金
关键词
细胞膜
膜蛋白
膜脂质
分子构象
伴刀豆球蛋白A
Headings Membrane proteins/chem
Membrane
lipids/chem
Molecular comformation/drug eff
